{"id":"W2768029665","doi":"10.1007/s13369-017-2914-3","title":"Reduction of Extracellular Proteases Increased Activity and Stability of Heterologous Protein in $${ Aspergillus}$$ A s p e r g i l l u s $${ niger}$$ n i g e r","year":2017,"lang":"en","type":"article","venue":"Arabian Journal for Science and Engineering","topic":"Enzyme Production and Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"Concordia University","funders":"Kementerian Sains, Teknologi dan Inovasi","keywords":"Heterologous; Cutinase; Biology; Proteases; Extracellular; Heterologous expression; Aspergillus niger; Mutant; Protease; Molecular biology; Biochemistry; Microbiology; Enzyme; Gene; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006736343,0.00005512813,0.00008890373,0.0000621654,0.0001372463,0.00003349566,0.00008917971,0.00003422053,7.428718e-7],"category_scores_gemma":[0.0004653835,0.00005147741,0.00001849524,0.0000429483,0.0001790983,0.00004899111,0.00003119354,0.0000536539,1.379971e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009065207,"about_ca_system_score_gemma":0.00004958342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001383026,"about_ca_topic_score_gemma":0.000004033196,"domain_scores_codex":[0.9995264,0.00001129817,0.0001308876,0.0001456474,0.00008337841,0.0001023323],"domain_scores_gemma":[0.9995626,0.000002439635,0.0001307992,0.0001387485,0.0001143527,0.00005101977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006039995,0.0000225437,0.003699358,0.00005332547,0.000003296503,2.536702e-7,0.00006283839,0.00002889062,0.9932975,0.00001689657,4.385303e-7,0.002754241],"study_design_scores_gemma":[0.0002389505,0.0001853591,0.05476929,0.00003505595,0.000002902434,0.00003536677,0.00003270796,0.000860221,0.9437137,0.00002473233,0.00004938679,0.00005228276],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985313,0.0001155165,0.0009880955,0.0001008782,0.00007435694,0.0001811266,0.000002912253,0.000001762768,0.000004081659],"genre_scores_gemma":[0.9992459,0.00004030205,0.0006512645,0.000001310951,0.00004171094,0.000008932373,8.44388e-7,0.000003727653,0.000006034654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05106993,"threshold_uncertainty_score":0.2099188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01426601109639761,"score_gpt":0.2452197439832117,"score_spread":0.2309537328868141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}