{"id":"W2768029665","doi":"10.1007/s13369-017-2914-3","title":"Reduction of Extracellular Proteases Increased Activity and Stability of Heterologous Protein in $${ Aspergillus}$$ A s p e r g i l l u s $${ niger}$$ n i g e r","year":2017,"lang":"en","type":"article","venue":"Arabian Journal for Science and Engineering","topic":"Enzyme Production and Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"Concordia University","funders":"Kementerian Sains, Teknologi dan Inovasi","keywords":"Heterologous; Cutinase; Biology; Proteases; Extracellular; Heterologous expression; Aspergillus niger; Mutant; Protease; Molecular biology; Biochemistry; Microbiology; Enzyme; Gene; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000105612,0.0004813947,0.0002180312,0.0001301725,0.00009980422,0.000356682,0.0002472753,0.0002423858,0.001743976],"category_scores_gemma":[0.0001357282,0.0001092298,0.0002905756,0.0001708164,0.0001334668,0.0001793316,0.0001802403,0.0006063972,0.0006672423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000216792,"about_ca_system_score_gemma":0.000164097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009307886,"about_ca_topic_score_gemma":0.0009506593,"domain_scores_codex":[0.9998606,0.00001976374,0.00001849531,0.00003512258,0.00003378727,0.00003223281],"domain_scores_gemma":[0.9999095,0.00001452308,0.00002089972,0.00001846856,0.00001689624,0.00001973907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006103549,0.00002091168,0.00005379802,0.00001223638,0.000003558351,0.0000208569,0.000005375753,0.00002779922,0.9991381,0.00007557159,0.00003474479,0.0005459462],"study_design_scores_gemma":[0.000002672483,0.00005924361,0.0007445039,0.000001927426,0.000006522408,0.00008660351,0.000007929489,0.0002598042,0.9977478,0.00002353938,0.001057353,0.000002010299],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914654,0.001051924,0.004046914,0.0001786764,0.00009192932,0.00001355028,0.0007266884,0.0001296667,0.002295125],"genre_scores_gemma":[0.9896359,0.0003667907,0.002332823,0.00005787437,0.00000976428,0.00001062862,0.001564841,0.00005902688,0.005962339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001743976,"threshold_uncertainty_score":0.005834162,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01426601109639761,"score_gpt":0.2452197439832117,"score_spread":0.2309537328868141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}