{"id":"W2768159483","doi":"10.1016/j.tcb.2017.10.006","title":"Cell-Autonomous Metabolic Reprogramming in Hypoxia","year":2017,"lang":"en","type":"review","venue":"Trends in Cell Biology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Sunnybrook Health Science Centre","funders":"","keywords":"Biology; Epigenetics; Reprogramming; Citric acid cycle; Metabolic pathway; Cell biology; Mitochondrion; Cellular respiration; Hypoxia (environmental); Biochemistry; Metabolism; Cell; Chemistry; Oxygen; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.000627125,0.0007303194,0.002299501,0.0007002465,0.00008119877,0.000043859,0.001038709,0.001465756,0.00008223964],"category_scores_gemma":[0.00006743069,0.0006594648,0.0007136044,0.0003240069,0.0002353305,0.00000501488,0.0004511349,0.0006678644,0.00005430071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005108919,"about_ca_system_score_gemma":0.0003553958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003392249,"about_ca_topic_score_gemma":0.000607332,"domain_scores_codex":[0.9961904,0.0003855737,0.0009915003,0.001435721,0.00008650959,0.0009103023],"domain_scores_gemma":[0.9974405,0.00003935394,0.0006829532,0.001665806,0.00003249393,0.0001388548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001565265,0.0001293361,0.00003679632,0.000628289,0.00004484731,0.00001093187,0.00002494403,0.000001743164,0.0007024982,0.0000296187,0.0008889789,0.9974864],"study_design_scores_gemma":[0.0007513684,0.0001103979,0.00005820351,0.0002353466,0.000207223,0.00002483516,0.000007864757,0.00000123852,0.0003427999,0.00002135496,0.9975786,0.0006607427],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004078569,0.9800007,0.000007171914,0.00001035678,0.002396501,0.0003463208,0.00009306645,0.00002174634,0.01671629],"genre_scores_gemma":[0.0007107484,0.9875116,0.0004053248,0.00004634221,0.001939011,0.0002979067,0.001307528,0.00009707837,0.007684446],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9968256,"threshold_uncertainty_score":0.9998305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06240543453250246,"score_gpt":0.3637054027792612,"score_spread":0.3012999682467588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}