{"id":"W2768159483","doi":"10.1016/j.tcb.2017.10.006","title":"Cell-Autonomous Metabolic Reprogramming in Hypoxia","year":2017,"lang":"en","type":"review","venue":"Trends in Cell Biology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Sunnybrook Health Science Centre","funders":"","keywords":"Biology; Epigenetics; Reprogramming; Citric acid cycle; Metabolic pathway; Cell biology; Mitochondrion; Cellular respiration; Hypoxia (environmental); Biochemistry; Metabolism; Cell; Chemistry; Oxygen; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004228397,0.0007361296,0.001200594,0.0009166901,0.0002372957,0.001302408,0.0008923022,0.0009826205,0.003132058],"category_scores_gemma":[0.0003092587,0.0002396192,0.000322716,0.001197754,0.0005868255,0.001328788,0.0009507852,0.001753436,0.001879627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006732579,"about_ca_system_score_gemma":0.0007438287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005164271,"about_ca_topic_score_gemma":0.001178419,"domain_scores_codex":[0.9998845,0.00001349259,0.00001384248,0.00002325074,0.00004286012,0.00002203991],"domain_scores_gemma":[0.9998791,0.00003802488,0.00002044457,0.000005561464,0.00003512393,0.0000216701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001125453,0.00004526127,0.0001705499,0.01128001,0.00006020256,0.0003769685,0.00006353232,0.0004351391,0.01046233,0.01262814,0.03943478,0.9249306],"study_design_scores_gemma":[0.000009350209,0.000031516,0.0004103878,0.0009058261,0.00004864178,0.0005864608,0.00003977105,0.00008452275,0.001754634,0.002736098,0.9933785,0.00001426949],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002039872,0.9968373,0.0003470845,0.0005226117,0.0005141407,0.000003460395,0.00002921857,0.00001604984,0.001526139],"genre_scores_gemma":[0.001244591,0.9971228,0.0001500806,0.0002453145,0.0002202391,0.000004765115,0.00003932232,0.000002480878,0.0009703672],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003132058,"threshold_uncertainty_score":0.01047772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06240543453250246,"score_gpt":0.3637054027792612,"score_spread":0.3012999682467588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}