{"id":"W2768363808","doi":"10.1007/s00204-017-2099-2","title":"Benchmark dose analyses of multiple genetic toxicity endpoints permit robust, cross-tissue comparisons of MutaMouse responses to orally delivered benzo[a]pyrene","year":2017,"lang":"en","type":"article","venue":"Archives of Toxicology","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Health Canada","funders":"National Institute of Environmental Health Sciences; Natural Environment Research Council; Wellcome Trust; Sight Research UK; Cancer Research UK; Wellcome","keywords":"Carcinogen; Micronucleus test; Toxicity; Benzo(a)pyrene; Biology; Pharmacology; Toxicology; Chemistry; Genetics; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001909491,0.0002681781,0.0006807143,0.0001913282,0.0001977689,0.00002339254,0.0008958719,0.0001825324,0.00006926183],"category_scores_gemma":[0.0006362697,0.0002696722,0.0002789881,0.00006829258,0.0008213517,0.000008914994,0.0008141314,0.0001121109,0.000002024741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001306341,"about_ca_system_score_gemma":0.0001919057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005440617,"about_ca_topic_score_gemma":0.001975798,"domain_scores_codex":[0.9979274,0.0002273942,0.0007091353,0.0005386941,0.0002012542,0.0003961615],"domain_scores_gemma":[0.9975902,0.0001814924,0.000630773,0.001250358,0.000162668,0.0001845284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001545027,0.0004975852,0.09215789,0.00007457517,0.0002283005,0.00001212707,0.000213443,0.005459419,0.8973231,0.00002891548,0.0001674835,0.002292156],"study_design_scores_gemma":[0.0008131269,0.00146624,0.4199716,0.00001907292,0.000053537,0.000009438286,0.00005919778,0.0003448837,0.5768834,0.0000381149,0.000192999,0.0001483158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942324,0.0003866995,0.003557349,0.0001336758,0.0001059837,0.0004414599,0.0005805804,0.000006262135,0.0005555874],"genre_scores_gemma":[0.971857,0.000119083,0.0274775,0.00007260381,0.00006372691,0.00002429594,0.00006083318,0.00002429796,0.0003007223],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3278137,"threshold_uncertainty_score":0.9999756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0491782169840073,"score_gpt":0.3646120449449791,"score_spread":0.3154338279609717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}