{"id":"W2768406646","doi":"10.1186/s12883-017-0978-z","title":"Parkinson disease polygenic risk score is associated with Parkinson disease status and age at onset but not with alpha-synuclein cerebrospinal fluid levels","year":2017,"lang":"en","type":"article","venue":"BMC Neurology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; BrightFocus Foundation; National Institute on Drug Abuse; Alzheimer's Association; National Institute on Aging; Weston Brain Institute; Foundation for Barnes-Jewish Hospital; Washington University in St. Louis; Michael J. Fox Foundation for Parkinson's Research; American Parkinson Disease Association; American Federation for Aging Research; American Parkinson's Disease Foundation","keywords":"Neurology; Genome-wide association study; Genetic architecture; Medicine; Disease; Genetic association; Cerebrospinal fluid; Parkinson's disease; Biomarker; Oncology; Internal medicine; Heritability; Single-nucleotide polymorphism; Neurochemistry; Bioinformatics; Genotype; Biology; Phenotype; Genetics; Gene; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002674645,0.0008321591,0.001296984,0.001336267,0.000575027,0.001170714,0.0006264285,0.0007171063,0.004785295],"category_scores_gemma":[0.006916551,0.0004255664,0.004122885,0.003000378,0.0003507205,0.0005081117,0.000856593,0.0008940924,0.000368048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002333282,"about_ca_system_score_gemma":0.00033141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008311266,"about_ca_topic_score_gemma":0.007785942,"domain_scores_codex":[0.9968359,0.001050094,0.0003647327,0.001277935,0.0002732032,0.0001981839],"domain_scores_gemma":[0.9955015,0.002221557,0.00102457,0.0007720702,0.0002540085,0.0002263825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001463728,0.00003121395,0.9784143,0.0001545802,0.01117026,0.0003577143,0.00006387729,0.0008517663,0.0009515774,0.0001697694,0.0008385345,0.005532708],"study_design_scores_gemma":[0.0001466681,0.0002012538,0.9855061,0.00004912104,0.00607824,0.001137358,0.00006429441,0.004778153,0.0002409557,0.0006804246,0.001092032,0.00002558411],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883347,0.002637877,0.002699907,0.0002972043,0.00007085897,0.00002161851,0.004942942,0.00009433398,0.0009006078],"genre_scores_gemma":[0.9965426,0.0002659649,0.0005748046,0.00004227473,0.00003013325,0.00001647058,0.002255138,0.00001527382,0.0002572033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008311266,"threshold_uncertainty_score":0.0165258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03382496579508947,"score_gpt":0.2644397012237546,"score_spread":0.2306147354286651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}