{"id":"W2768407971","doi":"10.1021/acs.chemrestox.7b00266","title":"Conformational Preference and Fluorescence Response of a C-Linked C8-Biphenyl-Guanine Lesion in the <i>Nar</i>I Mutational Hotspot: Evidence for Enhanced <i>Syn</i> Adduct Formation","year":2017,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; University of Lethbridge","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Chemistry; Adduct; Stereochemistry; Oligonucleotide; Moiety; Guanine; DNA; Duplex (building); Biochemistry; Nucleotide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002142479,0.0001124442,0.0001645824,0.00006460879,0.0001383038,0.00003814997,0.000638607,0.0002439374,0.00001130171],"category_scores_gemma":[0.005980668,0.00009281692,0.0000396385,0.00008935,0.0006684547,0.00004229814,0.000250921,0.000275267,0.000001604507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004740752,"about_ca_system_score_gemma":0.0002288551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008512096,"about_ca_topic_score_gemma":0.00001093634,"domain_scores_codex":[0.9985062,0.0001804762,0.000355727,0.0003025842,0.0003156143,0.0003393974],"domain_scores_gemma":[0.9982138,0.0009179139,0.0001510047,0.0004081556,0.0002448314,0.00006425298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003086177,0.00008143381,0.000295194,0.0001183015,0.000004380281,0.000002624345,0.0002759389,0.000004389911,0.9936139,0.0001596291,0.0004566213,0.001901438],"study_design_scores_gemma":[0.001167954,0.0002949455,0.009491466,0.0001346005,0.000002880016,0.00002092327,0.0002264005,0.0006065515,0.9866633,0.0008980984,0.0003933321,0.00009954402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973351,0.0002057618,0.0001996419,0.001417667,0.0000269738,0.0004486659,0.000027849,0.000002792027,0.0003354946],"genre_scores_gemma":[0.9984108,0.0002134825,0.0008612174,0.0001070171,0.00006684391,0.0002123239,0.00007586584,0.000007274663,0.0000452377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009196272,"threshold_uncertainty_score":0.715985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.228895920783137,"score_gpt":0.4383917528545397,"score_spread":0.2094958320714027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}