{"id":"W2768407971","doi":"10.1021/acs.chemrestox.7b00266","title":"Conformational Preference and Fluorescence Response of a C-Linked C8-Biphenyl-Guanine Lesion in the <i>Nar</i>I Mutational Hotspot: Evidence for Enhanced <i>Syn</i> Adduct Formation","year":2017,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; University of Lethbridge","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Chemistry; Adduct; Stereochemistry; Oligonucleotide; Moiety; Guanine; DNA; Duplex (building); Biochemistry; Nucleotide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001096548,0.0001794147,0.0001104806,0.0001016811,0.0001055878,0.0001125114,0.0001593264,0.0002738248,0.001343503],"category_scores_gemma":[0.0001469303,0.0001138376,0.0001244655,0.00009523692,0.0001719822,0.0001050566,0.00008715616,0.0003209491,0.0002097917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001936373,"about_ca_system_score_gemma":0.00007440835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001046576,"about_ca_topic_score_gemma":0.001010098,"domain_scores_codex":[0.9999284,0.00001283197,0.000002777986,0.00002116927,0.00001414539,0.00002068118],"domain_scores_gemma":[0.9998336,0.00003636272,0.00005488807,0.00001184793,0.00002215442,0.00004110789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003921355,0.000008701985,0.0001513002,0.000006934275,0.000001990587,0.00001531346,0.00001377182,0.00005252189,0.9994566,0.00001337739,0.00001015054,0.0002300999],"study_design_scores_gemma":[0.000003550583,0.0001833641,0.004611013,0.000001802324,0.000006551351,0.00009562985,0.00002674997,0.0007714322,0.994089,0.00001165048,0.0001942319,0.000005023306],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986849,0.00008683321,0.0007550675,0.00001811506,0.000002462284,0.000003564551,0.00006528656,0.0000180298,0.0003655984],"genre_scores_gemma":[0.9982114,0.0001008079,0.0008394822,0.00002260099,0.000001498042,0.000007351007,0.0001570101,0.000009384961,0.000650437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001343503,"threshold_uncertainty_score":0.004494429,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.228895920783137,"score_gpt":0.4383917528545397,"score_spread":0.2094958320714027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}