{"id":"W2768424037","doi":"10.1111/boc.201700059","title":"PERK leads a hub dictating pancreatic β cell homoeostasis","year":2017,"lang":"en","type":"review","venue":"Biology of the Cell","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research; Servier","keywords":"Biology; Endoplasmic reticulum; Homeostasis; Cell; Cell biology; Embryonic stem cell; Kinase; Diabetes mellitus; Beta cell; Glucose homeostasis; Pathogenesis; Bioinformatics; Endocrinology; Immunology; Gene; Insulin resistance; Genetics; Islet","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002562607,0.0005384789,0.0006788902,0.0008015079,0.0002318542,0.0008286222,0.0005611545,0.000608124,0.002956705],"category_scores_gemma":[0.0002997201,0.0001544712,0.0002635774,0.0006485747,0.000375515,0.0008856108,0.0006513046,0.001331961,0.002489375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003979494,"about_ca_system_score_gemma":0.0005453923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002614514,"about_ca_topic_score_gemma":0.0003924056,"domain_scores_codex":[0.9999166,0.000009711575,0.00001318751,0.00001785501,0.00003029704,0.00001237695],"domain_scores_gemma":[0.9999294,0.00002460553,0.00001306649,0.00000317119,0.00001714995,0.00001252136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001565012,0.00004794752,0.0002900009,0.01101623,0.00008243048,0.0004845722,0.00006807852,0.000503452,0.01064616,0.01200684,0.03975227,0.9249456],"study_design_scores_gemma":[0.00001282367,0.0000513275,0.0006188385,0.0009621139,0.00004509658,0.001075002,0.00004332996,0.00007559706,0.002112641,0.003640241,0.991347,0.00001588054],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004914602,0.9954378,0.0003645823,0.0005862705,0.0005071445,0.000005507879,0.00005506227,0.000032586,0.002519658],"genre_scores_gemma":[0.002484516,0.995382,0.0002539308,0.0002559915,0.0001811656,0.000006395325,0.00007102637,0.000004191845,0.001360653],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002956705,"threshold_uncertainty_score":0.009891212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08983769084683953,"score_gpt":0.3536937029018829,"score_spread":0.2638560120550434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}