{"id":"W2768465599","doi":"10.1021/acs.jmedchem.7b01525","title":"Design, Synthesis, and Biological Assessment of Biased Allosteric Modulation of the Urotensin II Receptor Using Achiral 1,3,4-Benzotriazepin-2-one Turn Mimics","year":2017,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Institut National de la Recherche Scientifique","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chemistry; Urotensin-II; Tripeptide; Allosteric regulation; Peptide; Stereochemistry; Potency; Receptor; Glycine; Vasoconstriction; Antagonist; In vivo; Amino acid; Biochemistry; In vitro; Endocrinology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001062357,0.0002781765,0.000193148,0.00009321151,0.0000639313,0.000179768,0.0002366989,0.0001786491,0.0008004904],"category_scores_gemma":[0.0001110042,0.0001191458,0.0001349992,0.00009104673,0.0001084585,0.0001525819,0.0001280363,0.0002711952,0.0002638353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002037457,"about_ca_system_score_gemma":0.0001248607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002433096,"about_ca_topic_score_gemma":0.0003950206,"domain_scores_codex":[0.9999355,0.00001212913,0.000005502283,0.00001343404,0.00001522704,0.00001819327],"domain_scores_gemma":[0.9999435,0.000005437253,0.00002199214,0.000004572971,0.000007474363,0.00001710238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001038893,0.00002961604,0.00007084086,0.00004731582,0.00000687304,0.00005934394,0.00001336661,0.0004345446,0.9973791,0.0001014304,0.00002757332,0.001726155],"study_design_scores_gemma":[0.00005939202,0.001311219,0.0009636154,0.000004592994,0.00002456602,0.0001396199,0.00001440399,0.001195306,0.9943125,0.0000267737,0.001938099,0.000009927976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921464,0.001198677,0.004555289,0.00005161974,0.00002180899,0.00009369241,0.0001895804,0.00006201307,0.001680895],"genre_scores_gemma":[0.9938391,0.001246196,0.003201087,0.00005357739,0.000009106059,0.0000624664,0.0001955077,0.000009659124,0.001383257],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008004904,"threshold_uncertainty_score":0.002677917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1385632687602541,"score_gpt":0.3610617902534115,"score_spread":0.2224985214931574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}