{"id":"W2768617862","doi":"10.1016/j.cell.2017.10.003","title":"NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis","year":2017,"lang":"en","type":"article","venue":"Cell","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":245,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Servier; Pew Charitable Trusts","keywords":"Biology; NRF1; Cell biology; Cholesterol; Endoplasmic reticulum; Transcription factor; Liver X receptor; NPC1; Internal medicine; Biochemistry; Nuclear receptor; Gene; Intracellular; Endosome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001574109,0.0003674858,0.0003806856,0.0003149549,0.0003515621,0.0003561061,0.0002235849,0.000346474,0.00214304],"category_scores_gemma":[0.0001216373,0.0001292021,0.0002600262,0.0002186284,0.0002332361,0.0004863434,0.0002342633,0.0003828136,0.0008626707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004760251,"about_ca_system_score_gemma":0.0002587588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008600832,"about_ca_topic_score_gemma":0.001150618,"domain_scores_codex":[0.9999058,0.000008783645,0.000005469093,0.00002961599,0.00003399724,0.00001635636],"domain_scores_gemma":[0.999925,0.000006015849,0.00002054468,0.000006533219,0.00002178913,0.00002012604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002344458,0.00001981778,0.0004909902,0.0001180158,0.00001198459,0.0001236236,0.00001637371,0.00006342241,0.9915114,0.0007399259,0.0003647955,0.006305161],"study_design_scores_gemma":[0.00002493215,0.0001899023,0.01796513,0.00003127341,0.00003367251,0.001349262,0.00008632107,0.0006850524,0.9575334,0.001030778,0.02104697,0.00002342397],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9257487,0.02777246,0.02257268,0.003363382,0.0003056024,0.0001267234,0.006436349,0.0007470679,0.0129271],"genre_scores_gemma":[0.9580659,0.01081026,0.009105934,0.0004370504,0.00009513446,0.00004505033,0.00501124,0.00004334373,0.01638615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00214304,"threshold_uncertainty_score":0.007169247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02480286255229478,"score_gpt":0.2660651909464762,"score_spread":0.2412623283941815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}