{"id":"W2768617862","doi":"10.1016/j.cell.2017.10.003","title":"NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis","year":2017,"lang":"en","type":"article","venue":"Cell","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":245,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Servier; Pew Charitable Trusts","keywords":"Biology; NRF1; Cell biology; Cholesterol; Endoplasmic reticulum; Transcription factor; Liver X receptor; NPC1; Internal medicine; Biochemistry; Nuclear receptor; Gene; Intracellular; Endosome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005461205,0.0001968523,0.0001719799,0.00002183639,0.000193082,0.0001128888,0.0004840326,0.0001518368,0.0001461795],"category_scores_gemma":[0.00001861657,0.0001937534,0.0001044472,0.00001493632,0.00009276739,0.000008558668,0.0001923736,0.00008280899,0.0001055258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001388262,"about_ca_system_score_gemma":0.00002708371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004995395,"about_ca_topic_score_gemma":0.00002517914,"domain_scores_codex":[0.9988478,0.0000228924,0.0001287291,0.0005025471,0.0001059565,0.000392104],"domain_scores_gemma":[0.9985639,0.000003417157,0.00009743166,0.001018783,0.00005818037,0.0002583233],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005190126,0.0000694315,0.003714374,0.00002357597,0.00002789088,0.00000250536,0.0003694919,0.000002718842,0.984951,8.130725e-7,0.009189942,0.001596317],"study_design_scores_gemma":[0.0004878852,0.00009641865,0.01393568,0.000007060565,0.00001996435,0.000002147849,0.0001190403,0.00000552628,0.9042813,0.00001534491,0.08079583,0.0002338395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947904,0.0002192745,0.0001318119,0.0007668202,0.0002260858,0.000190819,0.0002183134,0.000009148782,0.003447369],"genre_scores_gemma":[0.9930006,0.0002013158,0.0005444575,0.002628458,0.0004488598,0.00001012842,0.00009176526,0.00003190629,0.003042465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08066978,"threshold_uncertainty_score":0.7901034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02480286255229478,"score_gpt":0.2660651909464762,"score_spread":0.2412623283941815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}