{"id":"W2768713198","doi":"10.2174/1566523217666171122094629","title":"CRISPR/Cas9 Gene Editing: From Basic Mechanisms to Improved Strategies for Enhanced Genome Engineering In Vivo","year":2017,"lang":"en","type":"review","venue":"Current Gene Therapy","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"CRISPR; Genome editing; Cas9; Homologous recombination; Genome; Biology; Computational biology; Genome engineering; Genetics; Gene; Homology directed repair; DNA repair; DNA mismatch repair","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005207352,0.000688654,0.0009067208,0.002071517,0.0001782504,0.0008768285,0.0008368252,0.000919212,0.002191424],"category_scores_gemma":[0.0004167353,0.0002630998,0.0004929723,0.001317692,0.0005775041,0.001007335,0.0005227001,0.002135759,0.001497612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000684768,"about_ca_system_score_gemma":0.0007516405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005999592,"about_ca_topic_score_gemma":0.0007913762,"domain_scores_codex":[0.9997732,0.00003042733,0.00002709824,0.00003976906,0.0001070442,0.00002248727],"domain_scores_gemma":[0.9997914,0.00009496041,0.00003362267,0.000008433306,0.0000483591,0.00002316983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005076495,0.00007073703,0.0001796969,0.01630187,0.00008790808,0.0003923232,0.00007843322,0.0007484099,0.01974817,0.01005392,0.02765831,0.9246295],"study_design_scores_gemma":[0.000009972189,0.00006486,0.0004614008,0.001429482,0.00005240889,0.001631111,0.00003369175,0.0001907074,0.00585195,0.002751948,0.9874956,0.00002688871],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003906324,0.9932925,0.002144357,0.0008521531,0.0003758822,0.00001442686,0.00004835918,0.00005662977,0.002825078],"genre_scores_gemma":[0.001864749,0.9950498,0.001307393,0.0003639039,0.0001597421,0.00001306206,0.00007732991,0.000006429705,0.001157654],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002191424,"threshold_uncertainty_score":0.007331073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.050504660936735,"score_gpt":0.3814422626638076,"score_spread":0.3309376017270726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}