{"id":"W2768713198","doi":"10.2174/1566523217666171122094629","title":"CRISPR/Cas9 Gene Editing: From Basic Mechanisms to Improved Strategies for Enhanced Genome Engineering In Vivo","year":2017,"lang":"en","type":"review","venue":"Current Gene Therapy","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"CRISPR; Genome editing; Cas9; Homologous recombination; Genome; Biology; Computational biology; Genome engineering; Genetics; Gene; Homology directed repair; DNA repair; DNA mismatch repair","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002314254,0.0007235566,0.00113501,0.0001813066,0.00008661157,0.0001419124,0.000769719,0.0003824882,0.00002506314],"category_scores_gemma":[0.00004737262,0.0007039159,0.0004932312,0.00009664657,0.00001862684,0.00000808806,0.0001535896,0.0002470763,0.000007469536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006299823,"about_ca_system_score_gemma":0.0002493106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001335385,"about_ca_topic_score_gemma":0.00002052508,"domain_scores_codex":[0.9976493,0.00003606865,0.0006095134,0.000938905,0.0001411656,0.0006250865],"domain_scores_gemma":[0.9984941,0.00002939792,0.0002406736,0.0009764666,0.00007956025,0.0001797598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002781169,0.00004377974,1.114518e-7,0.0008719788,0.000152812,0.000001353547,0.00006830927,0.0003641578,0.6186576,0.00001279068,0.0001032813,0.379696],"study_design_scores_gemma":[0.0007322585,0.0002635686,0.000002398929,0.0006862104,0.00007790769,0.000003118267,0.000014222,0.00008058586,0.2349987,0.00005475018,0.7623845,0.0007018017],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001725809,0.7949791,0.1999235,0.000006078581,0.001512113,0.001415829,0.0003919262,0.00003214223,0.00001355929],"genre_scores_gemma":[0.001744611,0.9896507,0.003939308,0.00002110543,0.002495858,0.001037074,0.000871535,0.0001770133,0.00006279343],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7622812,"threshold_uncertainty_score":0.9995412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.050504660936735,"score_gpt":0.3814422626638076,"score_spread":0.3309376017270726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}