{"id":"W2768791003","doi":"10.1093/annonc/mdx665.036","title":"KEYNOTE-412: Phase 3 trial of pembrolizumab plus chemoradiation (CRT) vs CRT alone for locally advanced head and neck squamous cell carcinoma (LA-HNSCC)","year":2017,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Pembrolizumab; Medicine; Head and neck squamous-cell carcinoma; Internal medicine; Placebo; Head and neck cancer; Oncology; Regimen; Phases of clinical research; Larynx; Response Evaluation Criteria in Solid Tumors; Urology; Cancer; Surgery; Clinical trial; Immunotherapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001289784,0.001523031,0.00180556,0.0003798619,0.0005092254,0.001400516,0.00126295,0.001624563,0.01289733],"category_scores_gemma":[0.001021985,0.0005901878,0.002154052,0.0003669885,0.0008535067,0.001335443,0.000481824,0.004939333,0.002298416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001317662,"about_ca_system_score_gemma":0.001463596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002075001,"about_ca_topic_score_gemma":0.006314915,"domain_scores_codex":[0.9997265,0.0001041927,0.00001190481,0.00005910131,0.00002351796,0.00007477478],"domain_scores_gemma":[0.9995943,0.00008526635,0.00006177361,0.00003166847,0.00002487802,0.0002021343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8894723,0.0143497,0.00110882,0.001743966,0.001899217,0.0001246687,0.0001947251,0.002132032,0.01222194,0.0006410316,0.01017139,0.06594015],"study_design_scores_gemma":[0.9066419,0.08438284,0.002878375,0.00007059801,0.0006759407,0.00008396324,0.00007479584,0.000812137,0.0009649462,0.0005585855,0.002826368,0.00002952549],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9655387,0.006547291,0.0008662673,0.003071722,0.001560041,0.004949779,0.00658479,0.0004221431,0.01045925],"genre_scores_gemma":[0.9618083,0.004000174,0.002510442,0.003825354,0.0005226471,0.004938609,0.005739624,0.0001181864,0.0165367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01289733,"threshold_uncertainty_score":0.0431459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06201928635590589,"score_gpt":0.3964576480686435,"score_spread":0.3344383617127377,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}