{"id":"W2768809900","doi":"10.1016/j.bpj.2018.03.003","title":"Structure of Transmembrane Helix 8 and Possible Membrane Defects in CFTR","year":2018,"lang":"en","type":"letter","venue":"Biophysical Journal","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Canada Research Chairs; Canadian Institutes of Health Research; Sparks; Cystic Fibrosis Trust; Alberta Innovates - Health Solutions; Alberta Innovates - Technology Futures","keywords":"Cystic fibrosis transmembrane conductance regulator; Gating; ATP-binding cassette transporter; Biophysics; Transmembrane protein; ATP hydrolysis; Transmembrane domain; Chemistry; Transporter; Phosphorylation; Context (archaeology); Helix (gastropod); Molecular dynamics; Adenosine triphosphate; Biochemistry; Cell biology; Biology; Membrane; ATPase; Enzyme; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00111098,0.0009054405,0.00108584,0.0006600633,0.001680418,0.001302662,0.001740675,0.03532046,0.004675641],"category_scores_gemma":[0.01623296,0.0007067039,0.001283367,0.000362924,0.002392805,0.002613555,0.0009415075,0.01815111,0.002340087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00225799,"about_ca_system_score_gemma":0.0005608858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006835187,"about_ca_topic_score_gemma":0.0005049601,"domain_scores_codex":[0.999038,0.0002886462,0.0001494551,0.0001542675,0.0001955025,0.0001740747],"domain_scores_gemma":[0.9963611,0.002413423,0.0003681534,0.0002007318,0.0002534314,0.0004030827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001387965,0.0003566126,0.004468241,0.0002832713,0.0000844491,0.4681289,0.0005232921,0.0009921128,0.004723059,0.01575926,0.4847151,0.01857782],"study_design_scores_gemma":[0.002110335,0.001832903,0.01060483,0.0008464511,0.0004513159,0.3718989,0.001477268,0.01496733,0.009277533,0.09745616,0.4887747,0.0003022067],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.02570589,0.004028017,0.0007893634,0.9059169,0.05697628,0.00003697039,0.0001288498,0.00008448518,0.00633335],"genre_scores_gemma":[0.2915263,0.006005731,0.001831932,0.3528779,0.3349872,0.00009929261,0.0002614682,0.0001179023,0.01229222],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.03532046,"threshold_uncertainty_score":0.01638293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01228343874436461,"score_gpt":0.2855080628433215,"score_spread":0.2732246240989569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}