{"id":"W2768889465","doi":"10.1038/s41598-017-16687-6","title":"Profiling of the transcriptional response to all-trans retinoic acid in breast cancer cells reveals RARE-independent mechanisms of gene expression","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Killam Trusts; Dalhousie University; Nova Scotia Health Research Foundation; Canadian Imperial Bank of Commerce; Breast Cancer Society of Canada; Beatrice Hunter Cancer Research Institute; Cancer Research Institute","keywords":"Retinoic acid; Biology; Transcription factor; Cancer research; Retinoid; Breast cancer; Gene expression; Tretinoin; Regulation of gene expression; Retinoic acid receptor; Cancer cell; Gene expression profiling; Cancer; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000116909,0.0001526587,0.000245538,0.0002987219,0.0001707894,0.0003754867,0.0001003733,0.0001792148,0.0008956625],"category_scores_gemma":[0.0001071008,0.00009092769,0.0002166841,0.0003983986,0.0001616856,0.000128805,0.0001297774,0.0004343805,0.0004481468],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002449917,"about_ca_system_score_gemma":0.0002177191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007235986,"about_ca_topic_score_gemma":0.001562099,"domain_scores_codex":[0.9997892,0.00001929132,0.00001337361,0.00005404568,0.00008574178,0.00003849898],"domain_scores_gemma":[0.9999032,0.00001771219,0.0000225522,0.00001919513,0.0000191423,0.0000182033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004402242,0.000006125414,0.0005597526,0.00001228044,0.000002303115,0.00001182382,0.00001722043,0.00002334834,0.9983467,0.00003449946,0.00002078154,0.0009211068],"study_design_scores_gemma":[0.000005977327,0.0001342698,0.03095377,0.000005007503,0.0000169174,0.0002539795,0.0001043649,0.0005706269,0.9648355,0.00008287108,0.003031205,0.000005517669],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812231,0.003227038,0.01011879,0.0001379952,0.00002060693,0.00003857159,0.00294078,0.000139999,0.002153135],"genre_scores_gemma":[0.984723,0.002304647,0.006095867,0.0001061875,0.00001058629,0.00006471947,0.002850913,0.00003295069,0.003811198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008956625,"threshold_uncertainty_score":0.002996266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01193672844122485,"score_gpt":0.2619974552936525,"score_spread":0.2500607268524277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}