{"id":"W2768891580","doi":"10.13025/26699","title":"Novel genetic loci underlying human intracranial volume identified through genome-wide association","year":2016,"lang":"en","type":"article","venue":"ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway)","topic":"Neurological Disease Mechanisms and Treatments","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"California NanoSystems Institute; National Center for Advancing Translational Sciences; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Institute on Aging; Biomedical Research Council; Instituto de Salud Carlos III; National Health and Medical Research Council; Australian Research Council; National Heart, Lung, and Blood Institute; Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; Heart And Stroke Foundation Of Quebec; National Institutes of Health; Fundación Marqués de Valdecilla; Universität Greifswald; Medical Research Council; Epilepsy Society; University College London Hospitals NHS Foundation Trust; Mutuelle Générale de l'Education Nationale; Radboud Universitair Medisch Centrum; Genome Institute of Singapore; Universitair Medisch Centrum Groningen; Centre d'Imagerie BioMédicale; Leids Universitair Medisch Centrum; Japan Society for the Promotion of Science; Universitetet i Bergen; Sanofi; Broad Institute; Fondation de France; Erasmus Medisch Centrum; Vrije Universiteit Amsterdam; Fondation pour la Recherche Médicale; University of Minnesota; Universiteit Utrecht; National Institutes of Natural Sciences; ZonMw; University of Toronto; Stichting voor de Technische Wetenschappen; Centre for Cognitive Ageing and Cognitive Epidemiology; University of New South Wales; National Medical Research Council; Universiteit Leiden; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital; Institut National de la Santé et de la Recherche Médicale; University College London; Accare; Agency for Science, Technology and Research; European Commission; Centre hospitalier régional universitaire de Lille; Age UK; National University Health System; Alzheimer's Association; Scottish Funding Council; Hersenstichting; Radboud Universiteit; Koninklijke Nederlandse Akademie van Wetenschappen; Mrs Gladys Row Fogo Charitable Trust; Wellcome Trust; Hjartavernd; Bergens Forskningsstiftelse; Japan Agency for Medical Research and Development; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Bundesministerium für Bildung und Forschung; Ministry of Education, Culture, Sports, Science and Technology; Harvard University; Commonwealth Scientific and Industrial Research Organisation; National Institute for Health and Care Research; Science Foundation Ireland; Fondation Leducq; National Science Foundation; Translational Genomics Research Institute; Massachusetts General Hospital; GlaxoSmithKline; U.S. Department of Energy; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease; Max-Planck-Gesellschaft; Autism Speaks; Brain Research Imaging Centre, University of Edinburgh; Bristol-Myers Squibb; Royal College of Surgeons in Ireland; Norges Forskningsråd; Australian Government; Heart and Stroke Foundation of Canada; Directorate for Biological Sciences; Université de Lille","keywords":"Genome-wide association study; Genetic association; Human genome; Association (psychology); Biology; Volume (thermodynamics); Brain size; Genome; Genetics; Computational biology; Evolutionary biology; Gene; Medicine; Single-nucleotide polymorphism; Genotype; Psychology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.0005712755,0.0003356297,0.0005955056,0.0004502619,0.001866612,0.00006592455,0.001383958,0.0003206625,0.000622516],"category_scores_gemma":[0.0003710851,0.0003571338,0.000435509,0.0008939405,0.00102244,0.0008643954,0.0005948035,0.0004393999,0.0002071969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007268615,"about_ca_system_score_gemma":0.0002183683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002719115,"about_ca_topic_score_gemma":0.0002290039,"domain_scores_codex":[0.9950101,0.0008274625,0.0003420901,0.001148195,0.001727584,0.0009446133],"domain_scores_gemma":[0.9968986,0.0007423352,0.0005725033,0.0007880126,0.0006034392,0.0003951048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009325981,0.001278082,0.02746185,0.00009503894,0.0002570575,0.001601359,0.001087306,0.00003561974,0.9640031,0.001295933,0.0007228909,0.001229152],"study_design_scores_gemma":[0.01083572,0.002480606,0.9344972,0.0002313108,0.000442444,0.00004100992,0.002633223,0.0003023147,0.04278205,0.002300637,0.002468047,0.0009854005],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827458,0.0000471732,0.009933948,0.0007552764,0.0001861386,0.000628176,0.0001135644,0.0001164097,0.005473495],"genre_scores_gemma":[0.9803425,0.0002221213,0.0007107746,0.00004001166,0.00003804778,4.379902e-7,0.000006774532,0.00003160066,0.01860774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9212211,"threshold_uncertainty_score":0.9998881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07535198674024346,"score_gpt":0.2752179107601174,"score_spread":0.1998659240198739,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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