{"id":"W2768891580","doi":"10.13025/26699","title":"Novel genetic loci underlying human intracranial volume identified through genome-wide association","year":2016,"lang":"en","type":"article","venue":"ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway)","topic":"Neurological Disease Mechanisms and Treatments","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"California NanoSystems Institute; National Center for Advancing Translational Sciences; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Institute on Aging; Biomedical Research Council; Instituto de Salud Carlos III; National Health and Medical Research Council; Australian Research Council; National Heart, Lung, and Blood Institute; Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; Heart And Stroke Foundation Of Quebec; National Institutes of Health; Fundación Marqués de Valdecilla; Universität Greifswald; Medical Research Council; Epilepsy Society; University College London Hospitals NHS Foundation Trust; Mutuelle Générale de l'Education Nationale; Radboud Universitair Medisch Centrum; Genome Institute of Singapore; Universitair Medisch Centrum Groningen; Centre d'Imagerie BioMédicale; Leids Universitair Medisch Centrum; Japan Society for the Promotion of Science; Universitetet i Bergen; Sanofi; Broad Institute; Fondation de France; Erasmus Medisch Centrum; Vrije Universiteit Amsterdam; Fondation pour la Recherche Médicale; University of Minnesota; Universiteit Utrecht; National Institutes of Natural Sciences; ZonMw; University of Toronto; Stichting voor de Technische Wetenschappen; Centre for Cognitive Ageing and Cognitive Epidemiology; University of New South Wales; National Medical Research Council; Universiteit Leiden; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital; Institut National de la Santé et de la Recherche Médicale; University College London; Accare; Agency for Science, Technology and Research; European Commission; Centre hospitalier régional universitaire de Lille; Age UK; National University Health System; Alzheimer's Association; Scottish Funding Council; Hersenstichting; Radboud Universiteit; Koninklijke Nederlandse Akademie van Wetenschappen; Mrs Gladys Row Fogo Charitable Trust; Wellcome Trust; Hjartavernd; Bergens Forskningsstiftelse; Japan Agency for Medical Research and Development; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Bundesministerium für Bildung und Forschung; Ministry of Education, Culture, Sports, Science and Technology; Harvard University; Commonwealth Scientific and Industrial Research Organisation; National Institute for Health and Care Research; Science Foundation Ireland; Fondation Leducq; National Science Foundation; Translational Genomics Research Institute; Massachusetts General Hospital; GlaxoSmithKline; U.S. Department of Energy; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease; Max-Planck-Gesellschaft; Autism Speaks; Brain Research Imaging Centre, University of Edinburgh; Bristol-Myers Squibb; Royal College of Surgeons in Ireland; Norges Forskningsråd; Australian Government; Heart and Stroke Foundation of Canada; Directorate for Biological Sciences; Université de Lille","keywords":"Genome-wide association study; Genetic association; Human genome; Association (psychology); Biology; Volume (thermodynamics); Brain size; Genome; Genetics; Computational biology; Evolutionary biology; Gene; Medicine; Single-nucleotide polymorphism; Genotype; Psychology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004198964,0.0005184159,0.0002958767,0.001593965,0.0003887207,0.0007763218,0.0005925241,0.0006900356,0.003286272],"category_scores_gemma":[0.001270626,0.0002625385,0.0007936218,0.001502313,0.0003542399,0.0001727046,0.0004686976,0.0005312557,0.0003446102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000251981,"about_ca_system_score_gemma":0.0003905908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005325672,"about_ca_topic_score_gemma":0.006487492,"domain_scores_codex":[0.9995382,0.0001044454,0.00003341041,0.0001657475,0.0001032129,0.00005504507],"domain_scores_gemma":[0.9992942,0.0003325809,0.000206245,0.00006281058,0.00004665105,0.0000575216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003802571,0.000389748,0.7605118,0.0002763852,0.002971592,0.01383776,0.001073729,0.002437934,0.1416778,0.00370566,0.00588995,0.0634251],"study_design_scores_gemma":[0.0001389261,0.0001373681,0.9807985,0.00004488521,0.0008811575,0.003979988,0.000220066,0.002022589,0.005736243,0.002043839,0.003954016,0.00004243968],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890029,0.001189001,0.004021307,0.0006342781,0.00006729097,0.00002488341,0.002246321,0.0001161672,0.00269785],"genre_scores_gemma":[0.9946706,0.0004015144,0.002432249,0.00009919847,0.00004814749,0.00002086908,0.001233817,0.00002949992,0.001064081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005325672,"threshold_uncertainty_score":0.01099366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07535198674024346,"score_gpt":0.2752179107601174,"score_spread":0.1998659240198739,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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