{"id":"W2768948569","doi":"10.1001/jamapsychiatry.2017.3391","title":"Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia","year":2017,"lang":"en","type":"article","venue":"JAMA Psychiatry","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":148,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cilag; Janssen Pharmaceuticals; National Center for Research Resources; National Institute of Biomedical Imaging and Bioengineering; National Institute on Aging; Krajowy Naukowy Osrodek Wiodacy; Sahlgrenska Akademin; Medizinische Fakultät der Albert-Ludwigs-Universität Freiburg; National Health and Medical Research Council; Medical Research Council; Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University in St. Louis; European Commission; Canadian Institutes of Health Research; University of California, San Francisco; National Institutes of Health; Göteborgs Universitet; Merz Pharmaceuticals; Akershus Universitetssykehus; Biogen; Marcus och Amalia Wallenbergs minnesfond; IXICO; Turun Yliopistollinen Keskussairaala; National Research Centre; Academy of Finland; Servier; Uniwersytet Medyczny im. Piastów Slaskich we Wroclawiu; Rheinische Friedrich-Wilhelms-Universität Bonn; Sahlgrenska Universitetssjukhuset; Aristotle University of Thessaloniki; Fondation pour la Recherche sur Alzheimer; Radboud Universitair Medisch Centrum; Eli Lilly and Company; Universidade de Lisboa; Universität zu Köln; Bayer HealthCare; Institut National de la Santé et de la Recherche Médicale; H. Lundbeck A/S; National Institute for Health and Care Research; Université Pierre et Marie Curie; Turun Yliopisto; Deutsches Zentrum für Neurodegenerative Erkrankungen; South London and Maudsley NHS Foundation Trust; Belgian Federal Science Policy Office; Rigshospitalet; National and Kapodistrian University of Athens; Eisai; Leids Universitair Medisch Centrum; Sundhed og Sygdom, Det Frie Forskningsråd; Région Normandie; Vetenskapsrådet; Kuopion Yliopistollinen Sairaala; Karolinska Institutet; Fonds Wetenschappelijk Onderzoek; Dementia Collaborative Research Centres, Australia; Medpace; Bundesministerium für Bildung und Forschung; Radboud Universiteit; York University; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Universiteit Leiden; Alzheimer's Disease Neuroimaging Initiative; European Regional Development Fund; KU Leuven; Seoul National University; Universität Heidelberg; Technische Universität München; Imperial College London; King's College London; Gentofte Hospital; Deutsche Forschungsgemeinschaft; Ministero della Salute; Genentech; Janssen Research and Development; AstraZeneca; Avid Radiopharmaceuticals; Pfizer; Centre National de la Recherche Scientifique; Instituto de Salud Carlos III; Synarc; Australian Government; Vlaamse regering; Lui Che Woo Institute of Innovative Medicine; Agence Nationale de la Recherche; Instituto de Investigación Marqués de Valdecilla; EU Joint Programme – Neurodegenerative Disease Research; Universiteit Antwerpen; Northern California Institute for Research and Education; Sungkyunkwan University; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Alzheimer's Association; Thomas Jefferson University; Università degli Studi di Perugia; University of Pittsburgh; University of Pennsylvania; BioClinica; University of California, San Diego; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; U.S. Department of Defense; Itä-Suomen Yliopisto; Edith Cowan University; Lundbeckfonden; Albert-Ludwigs-Universität Freiburg; AXA Research Fund; Samsung; Foundation for the National Institutes of Health; University of Southern California; Bristol-Myers Squibb; Meso Scale Diagnostics; Science and Industry Endowment Fund; National Science Foundation","keywords":"Dementia; Association (psychology); Cognition; Amyloid (mycology); Medicine; Alzheimer's disease; Neuroscience; Psychology; Psychiatry; Clinical psychology; Internal medicine; Disease; Pathology; Psychotherapist","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001317215,0.0003194094,0.0003862114,0.0008469925,0.0004517215,0.0005501762,0.0003555306,0.0004170511,0.0008855914],"category_scores_gemma":[0.003906439,0.0002669916,0.0004790022,0.001019686,0.0002918908,0.0003935126,0.0003354063,0.0005263238,0.0001325286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002184886,"about_ca_system_score_gemma":0.0002815736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004703435,"about_ca_topic_score_gemma":0.005586382,"domain_scores_codex":[0.9994395,0.0001651626,0.0001008385,0.0001429609,0.00009644662,0.00005507104],"domain_scores_gemma":[0.9976954,0.0004414831,0.001169619,0.0001900108,0.0002808243,0.0002227528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001358716,0.0000212344,0.9990694,0.000009388084,0.00007394992,0.00003595929,0.00002585147,0.0000207323,0.00004614697,0.000005396782,0.00003416676,0.0005219735],"study_design_scores_gemma":[0.000008190819,0.0001054068,0.9994767,0.000004766949,0.00004177101,0.0001522076,0.00004192074,0.00008747036,0.00002211943,0.00002092816,0.00003649222,0.000001979966],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988695,0.0004640896,0.00006320015,0.00003478314,0.000005616349,0.00000559153,0.0002775404,0.000002759855,0.0002768753],"genre_scores_gemma":[0.9994805,0.0001077137,0.00006399896,0.00002153323,0.00001129477,0.000005502303,0.0002535941,7.770995e-7,0.00005500753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004703435,"threshold_uncertainty_score":0.009352088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01277714428165254,"score_gpt":0.2979574462663539,"score_spread":0.2851803019847013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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