{"id":"W2768948569","doi":"10.1001/jamapsychiatry.2017.3391","title":"Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia","year":2017,"lang":"en","type":"article","venue":"JAMA Psychiatry","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":148,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cilag; Janssen Pharmaceuticals; National Center for Research Resources; National Institute of Biomedical Imaging and Bioengineering; National Institute on Aging; Krajowy Naukowy Osrodek Wiodacy; Sahlgrenska Akademin; Medizinische Fakultät der Albert-Ludwigs-Universität Freiburg; National Health and Medical Research Council; Medical Research Council; Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University in St. Louis; European Commission; Canadian Institutes of Health Research; University of California, San Francisco; National Institutes of Health; Göteborgs Universitet; Merz Pharmaceuticals; Akershus Universitetssykehus; Biogen; Marcus och Amalia Wallenbergs minnesfond; IXICO; Turun Yliopistollinen Keskussairaala; National Research Centre; Academy of Finland; Servier; Uniwersytet Medyczny im. Piastów Slaskich we Wroclawiu; Rheinische Friedrich-Wilhelms-Universität Bonn; Sahlgrenska Universitetssjukhuset; Aristotle University of Thessaloniki; Fondation pour la Recherche sur Alzheimer; Radboud Universitair Medisch Centrum; Eli Lilly and Company; Universidade de Lisboa; Universität zu Köln; Bayer HealthCare; Institut National de la Santé et de la Recherche Médicale; H. Lundbeck A/S; National Institute for Health and Care Research; Université Pierre et Marie Curie; Turun Yliopisto; Deutsches Zentrum für Neurodegenerative Erkrankungen; South London and Maudsley NHS Foundation Trust; Belgian Federal Science Policy Office; Rigshospitalet; National and Kapodistrian University of Athens; Eisai; Leids Universitair Medisch Centrum; Sundhed og Sygdom, Det Frie Forskningsråd; Région Normandie; Vetenskapsrådet; Kuopion Yliopistollinen Sairaala; Karolinska Institutet; Fonds Wetenschappelijk Onderzoek; Dementia Collaborative Research Centres, Australia; Medpace; Bundesministerium für Bildung und Forschung; Radboud Universiteit; York University; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Universiteit Leiden; Alzheimer's Disease Neuroimaging Initiative; European Regional Development Fund; KU Leuven; Seoul National University; Universität Heidelberg; Technische Universität München; Imperial College London; King's College London; Gentofte Hospital; Deutsche Forschungsgemeinschaft; Ministero della Salute; Genentech; Janssen Research and Development; AstraZeneca; Avid Radiopharmaceuticals; Pfizer; Centre National de la Recherche Scientifique; Instituto de Salud Carlos III; Synarc; Australian Government; Vlaamse regering; Lui Che Woo Institute of Innovative Medicine; Agence Nationale de la Recherche; Instituto de Investigación Marqués de Valdecilla; EU Joint Programme – Neurodegenerative Disease Research; Universiteit Antwerpen; Northern California Institute for Research and Education; Sungkyunkwan University; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Alzheimer's Association; Thomas Jefferson University; Università degli Studi di Perugia; University of Pittsburgh; University of Pennsylvania; BioClinica; University of California, San Diego; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; U.S. Department of Defense; Itä-Suomen Yliopisto; Edith Cowan University; Lundbeckfonden; Albert-Ludwigs-Universität Freiburg; AXA Research Fund; Samsung; Foundation for the National Institutes of Health; University of Southern California; Bristol-Myers Squibb; Meso Scale Diagnostics; Science and Industry Endowment Fund; National Science Foundation","keywords":"Dementia; Association (psychology); Cognition; Amyloid (mycology); Medicine; Alzheimer's disease; Neuroscience; Psychology; Psychiatry; Clinical psychology; Internal medicine; Disease; Pathology; Psychotherapist","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004579634,0.0001168738,0.0002088209,0.0001689162,0.0002218805,0.00009383528,0.00008056933,0.00009842134,0.0002887608],"category_scores_gemma":[0.0002349796,0.0001008062,0.00006579803,0.0001190925,0.00007266703,0.0003556845,0.00003444246,0.0002716056,0.00002460499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008376757,"about_ca_system_score_gemma":0.0002193613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001835984,"about_ca_topic_score_gemma":0.0006862978,"domain_scores_codex":[0.9987088,0.00006434298,0.0002145289,0.0002397531,0.0005051827,0.000267421],"domain_scores_gemma":[0.9990685,0.00003744613,0.0003485057,0.0001954721,0.0002734955,0.00007656535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009477497,0.0003009422,0.989202,0.00008607876,0.0003417008,0.000004128149,0.0002301612,5.380837e-7,0.0001675944,0.00008921185,0.0008392543,0.00779064],"study_design_scores_gemma":[0.008907142,0.0006036827,0.9865348,0.0006925074,0.0003385028,0.00000813022,0.001538086,0.0001532428,0.0008242158,0.0001158863,0.0001783518,0.0001054064],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9688141,0.0001068572,0.0004460149,0.003914043,0.0002268852,0.000464073,0.00001297633,0.00002046503,0.02599457],"genre_scores_gemma":[0.9954465,0.00001336639,0.0008154027,0.0002466168,0.0001958882,0.0000439786,0.00004140185,0.00001678602,0.003180078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02663236,"threshold_uncertainty_score":0.4110757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01277714428165254,"score_gpt":0.2979574462663539,"score_spread":0.2851803019847013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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