{"id":"W2768987398","doi":"10.1001/jamapsychiatry.2017.3433","title":"Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder","year":2017,"lang":"en","type":"article","venue":"JAMA Psychiatry","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Movement Disorders; McGill University; Douglas Mental Health University Institute; McGill University Health Centre; Dalhousie University; Montreal Neurological Institute and Hospital","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Centro de Investigación Biomédica en Red de Salud Mental; National Institute of Child Health and Human Development; Johns Hopkins Bloomberg School of Public Health; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Università degli Studi di Cagliari; National Institute on Drug Abuse; Universität Heidelberg; RIKEN; Karl-Franzens-Universität Graz; Sahlgrenska Akademin; Montreal Neurological Institute and Hospital; University of New South Wales; Università degli Studi di Perugia; Seconda Università degli Studi di Napoli; Instituto de Salud Carlos III; Università degli Studi di Salerno; Universitat de Barcelona; U.S. Department of Veterans Affairs; Technische Universität Dresden; Medizinische Universität Graz; Dalhousie University; Dokkyo Medical University; Hokkaido University; Assistance publique-Hôpitaux de Paris; Agence Nationale de la Recherche; Università degli Studi di Napoli Federico II; Broad Institute; Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu; Karolinska Institutet; National Taiwan University; Institut National de la Santé et de la Recherche Médicale; Neuroscience Research Australia; Université de Lorraine; RIKEN Brain Science Institute; Rheinische Friedrich-Wilhelms-Universität Bonn; Hôpitaux Universitaires de Genève; Johns Hopkins University; University of California, San Diego; Université Paris Diderot; National Institutes of Health; McGill University Health Centre; National Institute of Mental Health; Massachusetts Institute of Technology; Universität Basel; Veterans Affairs San Diego Healthcare System; McGill University; University of Cincinnati; National Taiwan University Hospital","keywords":"Bipolar disorder; Genome-wide association study; Genetic association; Internal medicine; Lithium (medication); Bipolar II disorder; Mood; Mood disorders; Mood stabilizer; Major depressive disorder; Schizophrenia (object-oriented programming); Psychology; Oncology; Medicine; Clinical psychology; Psychiatry; Genotype; Genetics; Biology; Single-nucleotide polymorphism; Anxiety; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005687238,0.00009329609,0.0001508813,0.00006785183,0.0001161259,0.00002589419,0.00007677522,0.0001813293,0.000001602432],"category_scores_gemma":[0.0005574326,0.00008436109,0.0000261288,0.00003810503,0.00003725639,0.000007563611,0.00005446399,0.00004529497,6.589758e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001176264,"about_ca_system_score_gemma":0.0000649974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000942254,"about_ca_topic_score_gemma":0.002455104,"domain_scores_codex":[0.9993163,0.000105325,0.0001559959,0.0002258882,0.00005146148,0.0001449812],"domain_scores_gemma":[0.9993845,0.00004557609,0.0002455165,0.0002163174,0.00006569186,0.00004239776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00100556,0.00001823678,0.9599478,0.00001722781,0.00005523194,6.085963e-8,0.00006933208,0.00001639188,0.03093547,0.00005758891,0.0003561381,0.007520928],"study_design_scores_gemma":[0.001628556,0.0003875509,0.9920202,0.00002393223,0.00001843356,0.000001468195,0.00008106181,0.00006217282,0.001296821,0.0002551538,0.004120395,0.0001042586],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932452,0.0014802,0.0008153511,0.003917092,0.00008520805,0.0003550301,0.00002902131,0.000003557145,0.00006927807],"genre_scores_gemma":[0.991302,0.0002525473,0.007721977,0.00006767885,0.0001327457,0.00004043641,0.00001506681,0.0000175359,0.0004500609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03207237,"threshold_uncertainty_score":0.3440145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005880543683755055,"score_gpt":0.2553944373906643,"score_spread":0.2495138937069092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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