{"id":"W2768987398","doi":"10.1001/jamapsychiatry.2017.3433","title":"Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder","year":2017,"lang":"en","type":"article","venue":"JAMA Psychiatry","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Movement Disorders; McGill University; Douglas Mental Health University Institute; McGill University Health Centre; Dalhousie University; Montreal Neurological Institute and Hospital","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Centro de Investigación Biomédica en Red de Salud Mental; National Institute of Child Health and Human Development; Johns Hopkins Bloomberg School of Public Health; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Università degli Studi di Cagliari; National Institute on Drug Abuse; Universität Heidelberg; RIKEN; Karl-Franzens-Universität Graz; Sahlgrenska Akademin; Montreal Neurological Institute and Hospital; University of New South Wales; Università degli Studi di Perugia; Seconda Università degli Studi di Napoli; Instituto de Salud Carlos III; Università degli Studi di Salerno; Universitat de Barcelona; U.S. Department of Veterans Affairs; Technische Universität Dresden; Medizinische Universität Graz; Dalhousie University; Dokkyo Medical University; Hokkaido University; Assistance publique-Hôpitaux de Paris; Agence Nationale de la Recherche; Università degli Studi di Napoli Federico II; Broad Institute; Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu; Karolinska Institutet; National Taiwan University; Institut National de la Santé et de la Recherche Médicale; Neuroscience Research Australia; Université de Lorraine; RIKEN Brain Science Institute; Rheinische Friedrich-Wilhelms-Universität Bonn; Hôpitaux Universitaires de Genève; Johns Hopkins University; University of California, San Diego; Université Paris Diderot; National Institutes of Health; McGill University Health Centre; National Institute of Mental Health; Massachusetts Institute of Technology; Universität Basel; Veterans Affairs San Diego Healthcare System; McGill University; University of Cincinnati; National Taiwan University Hospital","keywords":"Bipolar disorder; Genome-wide association study; Genetic association; Internal medicine; Lithium (medication); Bipolar II disorder; Mood; Mood disorders; Mood stabilizer; Major depressive disorder; Schizophrenia (object-oriented programming); Psychology; Oncology; Medicine; Clinical psychology; Psychiatry; Genotype; Genetics; Biology; Single-nucleotide polymorphism; Anxiety; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008494128,0.0004186163,0.0003804164,0.0007333136,0.0004772002,0.0004790538,0.000276799,0.0003830171,0.002421706],"category_scores_gemma":[0.002046031,0.0001975874,0.001074953,0.001401408,0.0003233052,0.0002245362,0.0004128217,0.0004750075,0.0001320255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002453026,"about_ca_system_score_gemma":0.0003308945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007211552,"about_ca_topic_score_gemma":0.009088494,"domain_scores_codex":[0.9993624,0.000210108,0.0000804181,0.0001893722,0.00007928286,0.00007853013],"domain_scores_gemma":[0.9988814,0.0003078147,0.0004847526,0.0001242886,0.00007074203,0.0001309913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004759654,0.00002048604,0.9953874,0.00002046636,0.0006990705,0.00012205,0.00004097319,0.0001667467,0.000936743,0.00004845858,0.0001541751,0.001927532],"study_design_scores_gemma":[0.00001763185,0.00006121448,0.9982585,0.000008243788,0.0002768118,0.0001988798,0.00003715364,0.0008393337,0.00008129331,0.0001125274,0.000103678,0.000004825648],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981545,0.0004474016,0.0004393404,0.00011172,0.000008796486,0.000006424793,0.0006425826,0.00001012324,0.0001790766],"genre_scores_gemma":[0.9992251,0.00007549929,0.0002337585,0.00002159846,0.000006913503,0.000006144172,0.000347552,0.000003229714,0.00008011238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007211552,"threshold_uncertainty_score":0.01433921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005880543683755055,"score_gpt":0.2553944373906643,"score_spread":0.2495138937069092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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