{"id":"W2768994512","doi":"10.1016/j.freeradbiomed.2017.10.111","title":"Lysosomal Permeabilization Facilitate Mitochondria-mediated Cell Death in Ferroptosis and Oxytosis","year":2017,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"VDAC1; Programmed cell death; Cell biology; Mitochondrial permeability transition pore; Mitochondrion; Apoptosis; Voltage-dependent anion channel; Mitochondrial ROS; Chemistry; Biology; Biochemistry; Bacterial outer membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002998055,0.0002444886,0.0003166768,0.0002197672,0.0003554228,0.0003628295,0.0002639251,0.0005790342,0.002851537],"category_scores_gemma":[0.0003123888,0.0001660185,0.000263502,0.000144672,0.0003801267,0.0006657214,0.0004104003,0.000706514,0.0005307999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006133287,"about_ca_system_score_gemma":0.0002963894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006293287,"about_ca_topic_score_gemma":0.0008657034,"domain_scores_codex":[0.9997981,0.0000351173,0.0000215474,0.0000360404,0.00003768442,0.00007156035],"domain_scores_gemma":[0.9998141,0.0000474019,0.00004155783,0.00003374055,0.00002655521,0.00003664287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005767159,0.00003238753,0.0002339884,0.00005032422,0.00000605587,0.000187272,0.00004262839,0.00005067642,0.9972783,0.0007021815,0.00009573375,0.0007437459],"study_design_scores_gemma":[0.00002685888,0.0001135129,0.002479908,0.000005563339,0.000009597509,0.0005270615,0.00005527412,0.0004808891,0.9948973,0.0002695522,0.001130096,0.00000445329],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911029,0.001158707,0.005092034,0.0003293016,0.00004825663,0.00003732726,0.0002475082,0.0001086035,0.001875422],"genre_scores_gemma":[0.9965968,0.0002793745,0.001042837,0.0000478886,0.000009301973,0.00001868201,0.0001711978,0.0000198649,0.001814096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002851537,"threshold_uncertainty_score":0.009539366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02377679313542478,"score_gpt":0.2769223898440793,"score_spread":0.2531455967086545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}