{"id":"W2769003372","doi":"10.1016/j.phrs.2017.11.019","title":"Enantiomer-specific positive allosteric modulation of CB1 signaling in autaptic hippocampal neurons","year":2017,"lang":"en","type":"article","venue":"Pharmacological Research","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Eye Institute; National Institute on Drug Abuse; Canadian Institutes of Health Research","keywords":"Allosteric regulation; Hippocampal formation; Neuroscience; Chemistry; Enantiomer; Allosteric modulator; Cannabinoid receptor; Biology; Receptor; Biochemistry; Stereochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002183524,0.0001413929,0.0003602437,0.0004517533,0.0003716095,0.00009808759,0.0004304026,0.0001282794,0.001295756],"category_scores_gemma":[0.0007991094,0.0001103255,0.0001246591,0.0004356857,0.0007159945,0.0001551788,0.0003974493,0.001042241,0.00008902705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002190989,"about_ca_system_score_gemma":0.0002293151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001443047,"about_ca_topic_score_gemma":0.000007953021,"domain_scores_codex":[0.9967371,0.0004569766,0.0003822779,0.0004600589,0.00119913,0.000764469],"domain_scores_gemma":[0.9984738,0.0001857502,0.00009433898,0.0003784198,0.0005405704,0.0003271201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001005918,0.0005933529,0.008061091,0.00006858897,0.00002778258,0.0004342466,0.0001588401,0.00005329624,0.9599349,0.0002535659,0.002913229,0.02649513],"study_design_scores_gemma":[0.002419352,0.001216584,0.9328348,0.00009700779,0.00001756628,0.00002073692,0.000106869,0.005661766,0.05339773,0.0005623645,0.003527846,0.0001373701],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851095,0.0002686309,0.00003035449,0.009056287,0.0001108439,0.0009344726,0.00001311805,0.00001811952,0.004458637],"genre_scores_gemma":[0.9970334,0.0002806949,0.00006522143,0.00007089286,0.0001924618,0.0001069409,0.00001173405,0.00001966699,0.002219033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9247737,"threshold_uncertainty_score":0.9996172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.183566785020588,"score_gpt":0.4706947574095147,"score_spread":0.2871279723889267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}