{"id":"W2769006120","doi":"10.1016/bs.ctdb.2017.10.008","title":"Cell Polarity-Dependent Regulation of Cell Allocation and the First Lineage Specification in the Preimplantation Mouse Embryo","year":2017,"lang":"en","type":"review","venue":"Current topics in developmental biology/Current Topics in Developmental Biology","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Inner cell mass; Cell biology; Blastocyst; Blastomere; Biology; Embryo; Totipotent; Asymmetric cell division; Cell fate determination; Hippo signaling pathway; Cell; Cell division; Cell polarity; Genetics; Signal transduction; Embryonic stem cell; Embryogenesis; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003497117,0.0005853669,0.0007523858,0.0009913708,0.0001777065,0.0008561144,0.0008295268,0.0007519507,0.001674197],"category_scores_gemma":[0.0002904033,0.0002092138,0.0002167351,0.0008828355,0.0004073599,0.0007707734,0.0004821116,0.001120817,0.001215636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000577585,"about_ca_system_score_gemma":0.0007837247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006552522,"about_ca_topic_score_gemma":0.001234306,"domain_scores_codex":[0.9998957,0.00001032503,0.0000136254,0.00002361357,0.00004193139,0.00001479651],"domain_scores_gemma":[0.9998671,0.00004564485,0.00003184905,0.000004476022,0.00003353232,0.0000174535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001206822,0.00003831633,0.000319736,0.01279207,0.00006463887,0.0004008701,0.00007160291,0.0004941373,0.02795084,0.01295007,0.01586658,0.9289306],"study_design_scores_gemma":[0.00001669775,0.00006663466,0.00221685,0.001400578,0.00009213587,0.001303388,0.00006485227,0.0001104253,0.01127605,0.003426799,0.9799979,0.00002757047],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004694348,0.996572,0.0003903004,0.00024626,0.0002083549,0.000005438646,0.00003576849,0.00001262146,0.002059773],"genre_scores_gemma":[0.002300443,0.9958431,0.0002613271,0.0001636076,0.0001345308,0.000006910338,0.00005430635,0.000002822641,0.001232934],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001674197,"threshold_uncertainty_score":0.00560075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09956377977390082,"score_gpt":0.3564550094608289,"score_spread":0.2568912296869281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}