{"id":"W2769031876","doi":"10.1093/molbev/msx298","title":"Human-Specific Mutations and Positively Selected Sites in MARCO Confer Functional Changes","year":2017,"lang":"en","type":"article","venue":"Molecular Biology and Evolution","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; Genetics; Transmembrane domain; Gene; Serine; Scavenger receptor; Linkage disequilibrium; Single-nucleotide polymorphism; Genotype; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001695798,0.0003627329,0.0002255004,0.0002079537,0.0001883702,0.0001577291,0.000130808,0.0004581782,0.00273873],"category_scores_gemma":[0.0003250349,0.0001069872,0.0003169898,0.000170891,0.0002848352,0.00007522754,0.0002388492,0.0002640452,0.0004851149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001409699,"about_ca_system_score_gemma":0.0001566004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007454111,"about_ca_topic_score_gemma":0.001547123,"domain_scores_codex":[0.9998023,0.00003403914,0.00002248307,0.0000581794,0.00005015899,0.00003282368],"domain_scores_gemma":[0.9998143,0.00004720644,0.0000682447,0.00001995456,0.00001465436,0.00003561168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003729399,0.00008411347,0.01408712,0.00005903578,0.00004557779,0.003026173,0.0001053341,0.0001374317,0.9774948,0.0002671016,0.0001144146,0.004205979],"study_design_scores_gemma":[0.0002584966,0.001972062,0.3447599,0.00005914053,0.0002146347,0.04129673,0.0003138065,0.002667145,0.5927928,0.0004624264,0.01513694,0.00006602695],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980631,0.000183206,0.0006619067,0.00004523177,0.00002057107,0.0000180127,0.0002338456,0.00001627029,0.0007577401],"genre_scores_gemma":[0.9979123,0.0001114872,0.0008966246,0.00005949607,0.00001116859,0.000009558406,0.0002346974,0.00001196793,0.0007527143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00273873,"threshold_uncertainty_score":0.009162009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03747662633365643,"score_gpt":0.3489256637854884,"score_spread":0.3114490374518319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}