{"id":"W2769320453","doi":"10.3389/fphys.2017.00929","title":"Hoxa2 Inhibits Bone Morphogenetic Protein Signaling during Osteogenic Differentiation of the Palatal Mesenchyme","year":2017,"lang":"en","type":"article","venue":"Frontiers in Physiology","topic":"Cleft Lip and Palate Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; College of Pharmacy and Nutrition, University of Saskatchewan; American Cleft Palate-Craniofacial Association","keywords":"Mesenchyme; Cell biology; Noggin; Bone morphogenetic protein; RUNX2; Osteoblast; Biology; Homeobox; Embryonic stem cell; Bone morphogenetic protein 2; Bone morphogenetic protein 10; Bone morphogenetic protein 7; Transcription factor; Embryo; In vitro; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001368494,0.0003772872,0.0002770408,0.0002050886,0.0001949878,0.0003538831,0.0002614113,0.0002570903,0.001993775],"category_scores_gemma":[0.00008418328,0.0002399477,0.0002935323,0.0001625443,0.0002267282,0.0001493389,0.0002296678,0.0006964732,0.0005806792],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000167124,"about_ca_system_score_gemma":0.0003355809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007181314,"about_ca_topic_score_gemma":0.001478411,"domain_scores_codex":[0.9998042,0.00002496901,0.00001976185,0.00003625179,0.00006803989,0.00004679904],"domain_scores_gemma":[0.99994,0.00001088106,0.0000127442,0.000008813651,0.000007114135,0.00002033277],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008265192,0.00004944092,0.000131933,0.00003472478,0.000004635758,0.00003026676,0.000008925377,0.0000628866,0.9984028,0.0001025451,0.00007360734,0.001015613],"study_design_scores_gemma":[0.00002941358,0.0002889419,0.003079418,0.00000641861,0.0000157101,0.0001693455,0.00002539428,0.0008331217,0.9905723,0.00004296106,0.004933474,0.00000347484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855602,0.003150439,0.004320141,0.0002449689,0.0001220191,0.00007321462,0.0008558991,0.0002022664,0.005470657],"genre_scores_gemma":[0.984168,0.002259402,0.002683132,0.0001153658,0.00003003518,0.0001474106,0.001040394,0.00004897988,0.009507267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001993775,"threshold_uncertainty_score":0.006669819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009246668856170521,"score_gpt":0.2373064842454234,"score_spread":0.2280598153892529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}