{"id":"W2769320453","doi":"10.3389/fphys.2017.00929","title":"Hoxa2 Inhibits Bone Morphogenetic Protein Signaling during Osteogenic Differentiation of the Palatal Mesenchyme","year":2017,"lang":"en","type":"article","venue":"Frontiers in Physiology","topic":"Cleft Lip and Palate Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; College of Pharmacy and Nutrition, University of Saskatchewan; American Cleft Palate-Craniofacial Association","keywords":"Mesenchyme; Cell biology; Noggin; Bone morphogenetic protein; RUNX2; Osteoblast; Biology; Homeobox; Embryonic stem cell; Bone morphogenetic protein 2; Bone morphogenetic protein 10; Bone morphogenetic protein 7; Transcription factor; Embryo; In vitro; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001443873,0.000126565,0.000205589,0.00005172862,0.0002143256,0.00001547278,0.0004109727,0.000162513,0.00001173795],"category_scores_gemma":[0.0001296767,0.0001004016,0.0001152698,0.00005211958,0.0002279678,0.000005425248,0.0003524252,0.000170027,0.000001845631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001583564,"about_ca_system_score_gemma":0.00004871375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003452101,"about_ca_topic_score_gemma":0.00002906982,"domain_scores_codex":[0.9989071,0.0001601496,0.0002237681,0.0003022165,0.000123757,0.0002829841],"domain_scores_gemma":[0.9990755,0.000006025538,0.0001872465,0.0006488659,0.00004347482,0.00003882739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009722131,0.0000307901,0.0730924,0.00004415173,0.00003352293,9.835071e-7,0.00003836838,0.00008244805,0.9260826,0.000005972121,0.00006611353,0.0004254555],"study_design_scores_gemma":[0.0005082895,0.00005036074,0.3190689,0.00003265243,0.000006053371,0.000002530822,0.00002816029,0.0001072482,0.679776,0.0002634277,0.0000682043,0.00008820522],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998759,0.0003502881,0.00007312978,0.00008282175,0.0003083389,0.0003201328,0.00001488955,0.000003184234,0.00008816006],"genre_scores_gemma":[0.9991713,0.00008725474,0.000190287,0.000009507525,0.0001487436,0.00003113691,0.00003261161,0.00001567165,0.0003135173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2463066,"threshold_uncertainty_score":0.4094258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009246668856170521,"score_gpt":0.2373064842454234,"score_spread":0.2280598153892529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}