{"id":"W2769387217","doi":"10.1523/jneurosci.0936-17.2017","title":"Abnormal Microglia and Enhanced Inflammation-Related Gene Transcription in Mice with Conditional Deletion of<i>Ctcf</i>in<i>Camk2a-Cre</i>-Expressing Neurons","year":2017,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Advancing Translational Sciences; National Cancer Institute; Intellectual and Developmental Disabilities Research Center, Washington University School of Medicine in St. Louis; Alvin J. Siteman Cancer Center; National Institutes of Health; National Center for Research Resources; National Institute of Neurological Disorders and Stroke; Institute of Clinical and Translational Sciences; Intellectual and Developmental Disabilities Research Center; National Institute on Aging; Hope Center for Neurological Disorders; National Heart, Lung, and Blood Institute; McGill University","keywords":"CTCF; Biology; Microglia; Chromatin; Forebrain; Transcription factor; Cell biology; Neuroscience; Genetics; Gene; Inflammation; Immunology; Central nervous system; Enhancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001631313,0.0009375666,0.0004662906,0.001005875,0.000346079,0.0005683196,0.0003495807,0.0008593861,0.002665186],"category_scores_gemma":[0.0001715365,0.000511715,0.000560214,0.0002687858,0.0007037648,0.0002959137,0.0003992277,0.001401821,0.0007478876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005760311,"about_ca_system_score_gemma":0.0004132123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001748452,"about_ca_topic_score_gemma":0.003220296,"domain_scores_codex":[0.999549,0.00003265879,0.00005825987,0.0001390412,0.0001190173,0.0001020439],"domain_scores_gemma":[0.9994003,0.00003953207,0.0003125027,0.00003814044,0.00002822607,0.000181277],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000926124,0.00003505489,0.0001967441,0.00002365501,0.000006286331,0.0001663524,0.00002054168,0.00004302065,0.9989191,0.00008600271,0.00004359736,0.0003669115],"study_design_scores_gemma":[0.0001187997,0.0004597315,0.02859267,0.00004109204,0.00006769907,0.002539402,0.0001311433,0.001492074,0.9635074,0.0002581626,0.002763688,0.00002838008],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909993,0.0007784486,0.003827429,0.0002480965,0.000060753,0.00005021507,0.002292332,0.0003949122,0.00134858],"genre_scores_gemma":[0.9841648,0.0008417745,0.004854231,0.0002319839,0.00003319261,0.0001703142,0.001716711,0.0002993293,0.007687698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002665186,"threshold_uncertainty_score":0.008915961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02347041115029582,"score_gpt":0.2591146080194099,"score_spread":0.2356441968691141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}