{"id":"W2769549375","doi":"10.1080/14728222.2018.1406924","title":"Emerging therapeutic targets in myeloproliferative neoplasms and peripheral T-cell leukemia and lymphomas","year":2017,"lang":"en","type":"review","venue":"Expert Opinion on Therapeutic Targets","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Hungarian Scientific Research Fund; Canadian Institutes of Health Research; Austrian Science Fund; Österreichische Forschungsförderungsgesellschaft; Canada Research Chairs","keywords":"Biology; Cancer research; Epigenetics; Leukemia; Haematopoiesis; Chromatin remodeling; Myeloproliferative Disorders; JAK-STAT signaling pathway; Cancer; Lymphoma; Carcinogenesis; Signal transduction; Genetics; Immunology; Gene; Stem cell; Receptor tyrosine kinase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0007866081,0.001442369,0.003363503,0.0007599933,0.0005582201,0.0002534128,0.0005869099,0.001021731,0.00041047],"category_scores_gemma":[0.0001039815,0.00111437,0.0004412601,0.0002865223,0.0005334344,0.0002788443,0.0003261049,0.001684764,0.00007229122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002050813,"about_ca_system_score_gemma":0.0020503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001227636,"about_ca_topic_score_gemma":0.000014254,"domain_scores_codex":[0.9943866,0.0006654558,0.001138954,0.001697756,0.0008260136,0.001285232],"domain_scores_gemma":[0.9969537,0.0004694986,0.000588145,0.001294499,0.0001366735,0.0005574322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003700886,0.0001874569,0.00007490973,0.002410293,0.0004939758,0.0001621545,0.003519363,0.000001187212,0.00004084023,0.0003595557,0.0008266557,0.9915535],"study_design_scores_gemma":[0.004033765,0.0007568499,0.0001788275,0.00521693,0.00007598558,0.000423163,0.0003940686,0.0006795581,0.00006295305,0.0001584896,0.9869832,0.001036189],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003151124,0.9928846,0.00007284459,0.0006569015,0.0008847028,0.002766665,0.00003354784,0.0001247767,0.002544437],"genre_scores_gemma":[0.0008666004,0.9936814,0.000513381,0.001335828,0.0008111337,0.0006561177,0.000268083,0.0003128878,0.00155451],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9905173,"threshold_uncertainty_score":0.9998326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07735420331731752,"score_gpt":0.3934060889526299,"score_spread":0.3160518856353123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}