{"id":"W2769592746","doi":"10.1021/acschembio.7b00740","title":"Strictosidine Synthase Triggered Enantioselective Synthesis of N-Substituted (<i>S</i>)-3,14,18,19-Tetrahydroangustines as Novel Topoisomerase I Inhibitors","year":2017,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Ministry of Science and Technology of the People's Republic of China; Ministry of Education of the People's Republic of China; Natural Science Foundation of Zhejiang Province; National Natural Science Foundation of China","keywords":"Camptothecin; Topoisomerase; Stereochemistry; Cytotoxicity; Enantioselective synthesis; Enzyme; Enantiomer; Chemistry; Indole test; Biochemistry; In vitro; Combinatorial chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000788766,0.0002481085,0.0001706688,0.00007548602,0.00007324191,0.0001432746,0.0002373267,0.0001696721,0.0008902531],"category_scores_gemma":[0.00009651743,0.0001035779,0.0001625681,0.0001249691,0.00008675954,0.0001755613,0.000158019,0.000302257,0.0003784843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001745894,"about_ca_system_score_gemma":0.0002263314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000438589,"about_ca_topic_score_gemma":0.001334029,"domain_scores_codex":[0.9999583,0.000005641636,0.000003922917,0.00001022756,0.000008849885,0.0000130954],"domain_scores_gemma":[0.9999691,0.000002979059,0.00000884503,0.000004299605,0.000005436713,0.000009275365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000139941,0.00007780982,0.000196331,0.0001444638,0.00001495633,0.0002387814,0.00005035339,0.001326082,0.9904971,0.001212532,0.0002452862,0.005856296],"study_design_scores_gemma":[0.0000316329,0.0004082314,0.0005341185,0.000007204822,0.0000138087,0.0001454438,0.00001795694,0.003833235,0.9887289,0.0001162191,0.006151455,0.00001192086],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795178,0.001580273,0.008372048,0.0001018158,0.00006290736,0.0000894609,0.0006030361,0.0001314437,0.009541182],"genre_scores_gemma":[0.9905827,0.001193493,0.005966004,0.00003152901,0.000005988431,0.00003598706,0.0003414902,0.00002544769,0.001817342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008902531,"threshold_uncertainty_score":0.002978206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02027223850310627,"score_gpt":0.2897375574597496,"score_spread":0.2694653189566433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}