{"id":"W2769593282","doi":"10.1182/blood-2017-07-795047","title":"Final analysis of survival outcomes in the phase 3 FIRST trial of up-front treatment for multiple myeloma","year":2017,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":271,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen Elizabeth II Health Sciences Centre; Princess Margaret Cancer Centre; University of Calgary","funders":"National Cancer Institute; Celgene","keywords":"Multiple myeloma; Medicine; Internal medicine; Oncology; Progression-free survival; Overall survival; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005327185,0.000730161,0.001449058,0.0003366792,0.000298283,0.00100099,0.0007410722,0.0006748945,0.0103288],"category_scores_gemma":[0.003483189,0.0002243246,0.003998449,0.000393167,0.000423278,0.0006889763,0.0006126279,0.002060877,0.0009407848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007260864,"about_ca_system_score_gemma":0.001608051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009344504,"about_ca_topic_score_gemma":0.002612629,"domain_scores_codex":[0.9981976,0.001210474,0.00006556322,0.0001848778,0.0001311516,0.0002103567],"domain_scores_gemma":[0.9972785,0.0007693948,0.0007059582,0.0004784613,0.0001828407,0.0005848613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8907987,0.004646129,0.01450177,0.0009650899,0.008278574,0.0001815995,0.00008722628,0.002957104,0.0052465,0.0004203902,0.02156583,0.05035105],"study_design_scores_gemma":[0.5996208,0.2153613,0.135666,0.0003224515,0.01109591,0.0007519157,0.0001201318,0.004168968,0.005096362,0.00151113,0.02620101,0.00008408538],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9408494,0.007020957,0.002278948,0.001530067,0.0003651746,0.003922066,0.03343876,0.0002641396,0.01033045],"genre_scores_gemma":[0.9529777,0.001034912,0.003297205,0.001017325,0.0002299675,0.002811505,0.03041052,0.00009366295,0.008127198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0103288,"threshold_uncertainty_score":0.03455329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1205824684812269,"score_gpt":0.4038414628693454,"score_spread":0.2832589943881185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}