{"id":"W2769603806","doi":"10.1155/2017/6098107","title":"The eIF4E2‐Directed Hypoxic Cap‐Dependent Translation Machinery Reveals Novel Therapeutic Potential for Cancer Treatment","year":2017,"lang":"en","type":"review","venue":"Oxidative Medicine and Cellular Longevity","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society; Canadian Institutes of Health Research; Cancer Research Society","keywords":"EIF4E; Translation (biology); Cancer research; Cancer; Metastasis; Hypoxia (environmental); Cancer cell; Biology; Tumor microenvironment; Gene; Messenger RNA; Tumor cells; Chemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003867751,0.00063198,0.0008486288,0.001595913,0.0002591308,0.0007297797,0.0005789456,0.0008017107,0.003480391],"category_scores_gemma":[0.0004106551,0.0002312029,0.0003755231,0.00136586,0.0003404574,0.001133984,0.0005827309,0.001663075,0.002190045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005132153,"about_ca_system_score_gemma":0.0006865721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004745633,"about_ca_topic_score_gemma":0.001057114,"domain_scores_codex":[0.999899,0.00001289813,0.00001559772,0.00001755131,0.0000407548,0.00001416491],"domain_scores_gemma":[0.9998592,0.00005308591,0.00002105322,0.000005891772,0.00004281737,0.0000179567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008116198,0.00006773607,0.0001282395,0.01196145,0.000069791,0.0002146048,0.00005312757,0.0003503649,0.00441114,0.005703275,0.02949709,0.947462],"study_design_scores_gemma":[0.000009993975,0.00006437036,0.0003263253,0.0009701904,0.00004148729,0.0006680312,0.0000252804,0.000063322,0.0008208626,0.001364308,0.9956349,0.00001105492],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001794237,0.997332,0.000194427,0.0003081808,0.0003572267,0.00000531061,0.00002437567,0.00001028658,0.00158878],"genre_scores_gemma":[0.0008457847,0.9977174,0.0001959236,0.0001744451,0.0001496016,0.000006498336,0.0000402488,0.000001943852,0.0008681178],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003480391,"threshold_uncertainty_score":0.01164311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1015809061865542,"score_gpt":0.3653022370072324,"score_spread":0.2637213308206782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}