{"id":"W2769684200","doi":"10.3324/haematol.2017.175380","title":"Survival adjusting for crossover: phase 3 study of ibrutinib <i>vs</i> . chlorambucil in older patients with untreated chronic lymphocytic leukemia/small lymphocytic lymphoma","year":2017,"lang":"en","type":"letter","venue":"Haematologica","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Cancer Institute; Pharmacyclics","keywords":"Ibrutinib; Chlorambucil; Chronic lymphocytic leukemia; Internal medicine; Medicine; Leukemia; Lymphoma; Oncology; Hematology; Chemotherapy; Immunology; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0009652935,0.00176123,0.004953817,0.0008706938,0.0005379823,0.0002513281,0.00177084,0.002205448,0.0001915701],"category_scores_gemma":[0.001721889,0.001353421,0.000577271,0.0008025891,0.001038729,0.0002514367,0.0007191461,0.001271279,0.00008140608],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.1442935,"about_ca_system_score_gemma":0.07321973,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007522261,"about_ca_topic_score_gemma":0.0007381428,"domain_scores_codex":[0.9894912,0.0004445974,0.002376665,0.002616099,0.002282504,0.002788922],"domain_scores_gemma":[0.9907677,0.001856719,0.002138156,0.003557487,0.001265386,0.000414611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1501828,0.02098585,0.05277113,0.08590695,0.01158315,0.1543306,0.008068313,0.002900857,0.000155203,0.00009824103,0.4867529,0.02626408],"study_design_scores_gemma":[0.8951852,0.02461321,0.006128399,0.008195023,0.00335382,0.002494222,0.0006321558,0.02399483,0.001323845,0.00005092338,0.03067558,0.003352781],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842675,0.0006879927,0.00003912746,0.001762419,0.0005943272,0.01078834,0.0004183801,0.0003015283,0.00114044],"genre_scores_gemma":[0.9814235,0.00009360893,0.0002574559,0.01077659,0.001090094,0.001554638,0.002078447,0.0004627575,0.002262908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7450024,"threshold_uncertainty_score":0.9995133,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04148799816424028,"score_gpt":0.3180868482053957,"score_spread":0.2765988500411554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}