{"id":"W2769686732","doi":"10.1074/jbc.m117.814947","title":"Ligand-specific conformational transitions and intracellular transport are required for atypical chemokine receptor 3–mediated chemokine scavenging","year":2017,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; CHU Sainte-Justine Foundation","keywords":"Chemokine receptor; C-C chemokine receptor type 6; CXCL11; CCL21; XCL2; G protein-coupled receptor; Internalization; Chemokine; Chemotaxis; Cell biology; CCL25; CCR1; Chemistry; Ligand (biochemistry); Arrestin; Receptor; Biology; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004342876,0.0001926375,0.000345409,0.00002008591,0.0002670668,0.00005430947,0.0002827513,0.000376587,0.000146114],"category_scores_gemma":[0.0002272194,0.0001508868,0.0002273326,0.00002631906,0.0001822971,0.00001915858,0.00003302773,0.0002155559,0.000001120753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001868703,"about_ca_system_score_gemma":0.00004589471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":2.556565e-7,"about_ca_topic_score_gemma":1.540233e-7,"domain_scores_codex":[0.9988455,0.00001351359,0.0005207972,0.0002311017,0.0001495409,0.0002395394],"domain_scores_gemma":[0.998814,0.00003119132,0.000531137,0.000202083,0.0002404012,0.0001811757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000591234,0.00006861323,0.0004401917,0.00004534376,0.00006548874,0.000008600161,0.00002171219,0.00001072395,0.9977192,0.0000279106,0.0003005168,0.0007004567],"study_design_scores_gemma":[0.001612146,0.0002223707,0.001398683,0.00008171814,0.00002169966,0.0001415699,0.0001159728,0.00007809178,0.9767103,0.0001375996,0.01927185,0.0002079716],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877753,0.0008403987,0.01012759,0.0007817911,0.0001375534,0.0001229424,0.0001090025,0.000007957204,0.0000974966],"genre_scores_gemma":[0.9952595,0.0007513323,0.002671661,0.00007561605,0.0008721274,0.000009026983,0.0002741835,0.00001456253,0.00007205621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02100888,"threshold_uncertainty_score":0.6152983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02346891883994577,"score_gpt":0.2428214814645929,"score_spread":0.2193525626246471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}