{"id":"W2769726223","doi":"10.1016/j.freeradbiomed.2017.10.295","title":"Novel Regulatory Mechanism of STAT1 through Redox Post-translational Modification of Cysteines","year":2017,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"STAT1; Immune system; Chemistry; Cell biology; Mutant; Biology; Signal transduction; Biochemistry; Gene; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000233091,0.0002881237,0.0001848471,0.0001533034,0.000285223,0.0002303022,0.0003948484,0.0003494433,0.001567378],"category_scores_gemma":[0.0001336449,0.00009765951,0.0003450818,0.00008688754,0.0003224955,0.0003933539,0.0002602929,0.0004167518,0.0001979936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002801613,"about_ca_system_score_gemma":0.0002144166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002556159,"about_ca_topic_score_gemma":0.0003510358,"domain_scores_codex":[0.9999088,0.00001419839,0.000003738779,0.00002815067,0.00001542119,0.00002973045],"domain_scores_gemma":[0.9999428,0.000008168437,0.00001853398,0.000006389359,0.000009950107,0.00001426005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004476562,0.00004805463,0.0008935527,0.000108781,0.00002309106,0.0003293582,0.00008741351,0.0002347285,0.9903976,0.003084674,0.0002529133,0.004092055],"study_design_scores_gemma":[0.0001245335,0.0005643205,0.009280479,0.00001852462,0.00007670397,0.0008863063,0.0001312716,0.00551374,0.9733388,0.003843382,0.006188171,0.0000337348],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9755952,0.006783186,0.01335154,0.000758486,0.0002833518,0.00004270473,0.000198929,0.0001351496,0.002851396],"genre_scores_gemma":[0.9962924,0.0008239907,0.00136021,0.00009101378,0.00003310907,0.00001268374,0.00009707363,0.000006098177,0.001283398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001567378,"threshold_uncertainty_score":0.005243361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04752771928838951,"score_gpt":0.3430310137238166,"score_spread":0.2955032944354271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}