{"id":"W2769765347","doi":"10.1093/annonc/mdx729.007","title":"CNS response to osimertinib vs standard of care (SoC) EGFR-TKI as first-line therapy in patients (pts) with EGFR-TKI sensitising mutation (EGFRm)-positive advanced non-small cell lung cancer (NSCLC): Data from the FLAURA study","year":2017,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Osimertinib; Medicine; T790M; Oncology; Internal medicine; Gefitinib; Erlotinib; Lung cancer; non-small cell lung cancer (NSCLC); Cancer; Epidermal growth factor receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001384014,0.000434992,0.001467367,0.0003394406,0.0002194013,0.0007018098,0.0005034009,0.0006011251,0.001821629],"category_scores_gemma":[0.002075123,0.000186319,0.002113657,0.0005581189,0.0003860814,0.0005883115,0.0003371043,0.001400938,0.0002908502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001507422,"about_ca_system_score_gemma":0.0008875288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003635142,"about_ca_topic_score_gemma":0.01149597,"domain_scores_codex":[0.9993604,0.0002954378,0.00007013202,0.0001028914,0.00007218649,0.00009894482],"domain_scores_gemma":[0.9987288,0.0004105511,0.0004134391,0.00006621299,0.00006793521,0.0003129499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6574029,0.003871518,0.1700289,0.001578453,0.01186657,0.0004300188,0.0002774474,0.003722227,0.007805683,0.000285114,0.00901718,0.1337139],"study_design_scores_gemma":[0.1334687,0.1550161,0.6821069,0.0002910595,0.01277404,0.001277798,0.0004707259,0.002792721,0.003090936,0.0007696018,0.007822719,0.000118819],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934089,0.003460669,0.00005987157,0.0003225521,0.00007321501,0.00005565746,0.001372905,0.00001552908,0.001230692],"genre_scores_gemma":[0.9959001,0.001161927,0.00008957907,0.0004120027,0.000078604,0.00005623707,0.001841225,0.000008587023,0.0004518066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003635142,"threshold_uncertainty_score":0.01093709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04141203295170755,"score_gpt":0.4207739528017008,"score_spread":0.3793619198499932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}