{"id":"W2769777751","doi":"10.1161/atvb.36.suppl_1.18","title":"Abstract 18: Bempedoic Acid Lowers Low Density Lipoprotein-Cholesterol and Attenuates Aortic Atherosclerosis in LDL Receptor-Deficient ( LDLR +/- and LDLR -/- ) Yucatan Miniature Pigs","year":2016,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"LDL receptor; Internal medicine; Endocrinology; Familial hypercholesterolemia; ATP citrate lyase; Cholesterol; Chemistry; Lipoprotein; Low-density lipoprotein; Medicine; Biochemistry; Enzyme; Citrate synthase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001868739,0.0008020408,0.0007511477,0.0003957928,0.0002362747,0.0002911801,0.0005027456,0.0007502939,0.003183821],"category_scores_gemma":[0.0001513946,0.0002939922,0.0004181777,0.0001840708,0.0004701725,0.0003506195,0.0001705648,0.0009642187,0.0008055366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003567702,"about_ca_system_score_gemma":0.00041511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001157049,"about_ca_topic_score_gemma":0.001198847,"domain_scores_codex":[0.9998215,0.00003399651,0.00002442296,0.00003983862,0.00002969304,0.0000506434],"domain_scores_gemma":[0.9997166,0.00002937933,0.00008078704,0.00003294423,0.00003393419,0.0001063326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01018505,0.0009953881,0.0005028028,0.0001100834,0.00003100924,0.0001489863,0.00002094693,0.00004924696,0.9854801,0.00004179543,0.0001842631,0.002250287],"study_design_scores_gemma":[0.003217961,0.03341276,0.01887769,0.00003147746,0.0002174989,0.0007729893,0.00008289774,0.0006516651,0.9387707,0.00008384667,0.003853199,0.00002728468],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969571,0.0005407811,0.0006005485,0.0001365746,0.00005889736,0.00005730897,0.0008002935,0.00008352016,0.0007649724],"genre_scores_gemma":[0.9819843,0.001098473,0.002898993,0.0003044914,0.00007768408,0.0002030146,0.003216268,0.0000889699,0.01012765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003183821,"threshold_uncertainty_score":0.01065093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01455005992847795,"score_gpt":0.2406029713442296,"score_spread":0.2260529114157517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}