{"id":"W2769863953","doi":"10.1038/s41598-017-16029-6","title":"Identification of the Binding Sites on Rab5 and p110beta Phosphatidylinositol 3-kinase","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; Saskatchewan Cancer Agency","funders":"Saskatchewan Cancer Agency; University of Saskatchewan","keywords":"P110α; GTPase; GTPase-activating protein; GTP'; Phosphatidylinositol; Binding site; Endocytosis; Protein subunit; Small GTPase; Chemistry; Cell biology; GTP-binding protein regulators; Biochemistry; Mutant; Binding domain; G protein; Kinase; Biology; Signal transduction; Enzyme; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001152455,0.0003217628,0.0001787658,0.0001824099,0.0001481245,0.0001721727,0.0004083174,0.000291991,0.001247861],"category_scores_gemma":[0.0001643477,0.0001636475,0.0002598237,0.0001320704,0.0001622683,0.0001615665,0.0002346134,0.0003624187,0.0006250106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004519389,"about_ca_system_score_gemma":0.0001947836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001523558,"about_ca_topic_score_gemma":0.001356627,"domain_scores_codex":[0.9998837,0.00001833232,0.000007088906,0.00001934682,0.00003964602,0.00003193729],"domain_scores_gemma":[0.9999162,0.00001596724,0.00001713404,0.00001016468,0.0000119151,0.00002859831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001536115,0.00002945012,0.0004872313,0.00002810509,0.000005934318,0.00009313837,0.00001235153,0.0000905292,0.9969009,0.0002329196,0.00002747052,0.001938308],"study_design_scores_gemma":[0.00002350114,0.0001268376,0.01708863,0.000009028701,0.00002478742,0.0004334097,0.00004374674,0.002050834,0.9771489,0.0001339989,0.002908411,0.000007913549],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953366,0.0008513434,0.002164823,0.00006248039,0.000009394022,0.00001193723,0.0001538334,0.00002290923,0.001386811],"genre_scores_gemma":[0.9950764,0.0004352623,0.002044628,0.0000555284,0.000004026232,0.00001359653,0.0005404372,0.00001087177,0.001819312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001523558,"threshold_uncertainty_score":0.004174471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01157367565171139,"score_gpt":0.2442586885579628,"score_spread":0.2326850129062514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}