{"id":"W2769869761","doi":"10.1084/jem.20170869","title":"Rare PfCSP C-terminal antibodies induced by live sporozoite vaccination are ineffective against malaria infection","year":2017,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Malaria Research and Control","field":"Medicine","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"National Institute of Allergy and Infectious Diseases; National Research Council Canada; Government of Saskatchewan; Western Economic Diversification Canada; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canadian Light Source; Universiteit Leiden; Leids Universitair Medisch Centrum; Studienstiftung des Deutschen Volkes; Bundesministerium für Bildung und Forschung; National Institutes of Health; Deutsches Zentrum für Infektionsforschung; Canada Foundation for Innovation; International Max Planck Research School for Environmental, Cellular and Molecular Microbiology; University of Saskatchewan","keywords":"Circumsporozoite protein; Virology; Plasmodium falciparum; Antibody; Malaria vaccine; Epitope; Biology; Malaria; Immunization; Humoral immunity; Immunology; Immunity; Vaccination; Monoclonal antibody; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00107616,0.0002139502,0.0005412094,0.0001775079,0.0004510244,0.00003939839,0.0002730393,0.00008671667,0.000366757],"category_scores_gemma":[0.0009217911,0.0001219778,0.0001123707,0.00007074382,0.0001673113,0.0003911509,0.00009089875,0.0006138667,0.00001492533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002040056,"about_ca_system_score_gemma":0.00007743436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002277649,"about_ca_topic_score_gemma":0.00001484499,"domain_scores_codex":[0.9982296,0.0002080894,0.0004547966,0.0001404068,0.0006984567,0.0002686675],"domain_scores_gemma":[0.9979201,0.0001424675,0.0009201148,0.0003788543,0.0003971322,0.0002413461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004365796,0.0003843987,0.02173489,0.00005878224,0.0003112764,0.0003267095,0.002144284,0.000001124714,0.9605396,0.00007251656,0.004487556,0.005573058],"study_design_scores_gemma":[0.01211009,0.006305811,0.7707354,0.001192181,0.0002979018,0.001014317,0.003466889,0.0001972979,0.2040605,0.0000581958,0.0003815629,0.0001798584],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841043,0.00278216,0.00006112592,0.009817138,0.0005457619,0.0005598441,0.000004399516,0.00001361377,0.002111696],"genre_scores_gemma":[0.9975,0.0005389172,0.00002029123,0.0004899045,0.001149283,0.00001072091,0.00001051787,0.00002109279,0.0002592992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7564791,"threshold_uncertainty_score":0.497411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02427829606969362,"score_gpt":0.3458575382589308,"score_spread":0.3215792421892372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}