{"id":"W2769869761","doi":"10.1084/jem.20170869","title":"Rare PfCSP C-terminal antibodies induced by live sporozoite vaccination are ineffective against malaria infection","year":2017,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Malaria Research and Control","field":"Medicine","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"National Institute of Allergy and Infectious Diseases; National Research Council Canada; Government of Saskatchewan; Western Economic Diversification Canada; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canadian Light Source; Universiteit Leiden; Leids Universitair Medisch Centrum; Studienstiftung des Deutschen Volkes; Bundesministerium für Bildung und Forschung; National Institutes of Health; Deutsches Zentrum für Infektionsforschung; Canada Foundation for Innovation; International Max Planck Research School for Environmental, Cellular and Molecular Microbiology; University of Saskatchewan","keywords":"Circumsporozoite protein; Virology; Plasmodium falciparum; Antibody; Malaria vaccine; Epitope; Biology; Malaria; Immunization; Humoral immunity; Immunology; Immunity; Vaccination; Monoclonal antibody; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002445812,0.0003013429,0.0002347192,0.0001949042,0.0001032338,0.0001907357,0.0001418028,0.0002897639,0.001001075],"category_scores_gemma":[0.0002830769,0.00009285983,0.0001462864,0.00008325236,0.0002108744,0.0001304924,0.0001523038,0.0005630541,0.0001835588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001576971,"about_ca_system_score_gemma":0.0001128818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002500313,"about_ca_topic_score_gemma":0.0002042232,"domain_scores_codex":[0.9998204,0.00004135239,0.000013881,0.00003063836,0.00003075506,0.00006301807],"domain_scores_gemma":[0.9998041,0.00005674626,0.00004038467,0.00002817587,0.00002098387,0.00004965969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00017141,0.00007015584,0.001346179,0.00003451889,0.000009925298,0.0001061626,0.0000188417,0.00004350218,0.9950591,0.00009878832,0.00005895619,0.002982471],"study_design_scores_gemma":[0.0001076004,0.003619471,0.05583606,0.00003003151,0.0000843162,0.003931019,0.00006806549,0.00129833,0.9312035,0.0002156048,0.003598165,0.000007830065],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982204,0.0003674389,0.0004865774,0.00002663069,0.00001038777,0.00001274852,0.0000413777,0.00003071266,0.0008036721],"genre_scores_gemma":[0.9991663,0.0001387865,0.0002341961,0.0000377225,0.00001001791,0.000008201373,0.00009466908,0.000005277579,0.0003048792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001001075,"threshold_uncertainty_score":0.003348887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02427829606969362,"score_gpt":0.3458575382589308,"score_spread":0.3215792421892372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}