{"id":"W2769980455","doi":"10.1002/ajh.24980","title":"Intergroup LEAP trial (S1612): A randomized phase 2/3 platform trial to test novel therapeutics in medically less fit older adults with acute myeloid leukemia","year":2017,"lang":"en","type":"letter","venue":"American Journal of Hematology","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Jewish General Hospital; Queen's University; University of Alberta","funders":"National Cancer Institute","keywords":"Medicine; Randomized controlled trial; Cytarabine; Clinical trial; Oncology; Myeloid leukemia; Internal medicine; Intensive care medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003929848,0.002493042,0.00218275,0.0005536107,0.0005587533,0.001296973,0.001317397,0.002238421,0.01020092],"category_scores_gemma":[0.003340061,0.0003610754,0.002131289,0.000445501,0.001009839,0.001952853,0.00166195,0.005043818,0.002014623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009380713,"about_ca_system_score_gemma":0.002262213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005729555,"about_ca_topic_score_gemma":0.001727326,"domain_scores_codex":[0.9985937,0.0009103629,0.00003530515,0.0001810172,0.0001411292,0.0001383211],"domain_scores_gemma":[0.998558,0.0003753491,0.0002695607,0.0001201487,0.00008734921,0.0005895473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7912924,0.01085288,0.0033633,0.001863881,0.001770015,0.0003865203,0.0002512828,0.001775012,0.007507389,0.003683157,0.04116101,0.1360931],"study_design_scores_gemma":[0.8849256,0.09094609,0.003611518,0.0002370735,0.0005710531,0.0002827268,0.00005655157,0.001281446,0.001133242,0.002161196,0.0147384,0.00005513849],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8622875,0.01917248,0.006781203,0.02049262,0.003728031,0.02870494,0.02374201,0.001140743,0.03395046],"genre_scores_gemma":[0.8250274,0.008370563,0.02569978,0.02987198,0.003042432,0.05498096,0.02169134,0.0002792077,0.03103638],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01020092,"threshold_uncertainty_score":0.03412545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03236221611949127,"score_gpt":0.3474311390534881,"score_spread":0.3150689229339969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}