{"id":"W2770060394","doi":"10.1128/jvi.01790-17","title":"Authentic Patient-Derived Hepatitis C Virus Infects and Productively Replicates in Primary CD4 <sup>+</sup> and CD8 <sup>+</sup> T Lymphocytes <i>In Vitro</i>","year":2017,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Memorial University of Newfoundland","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Biology; Hepatitis C virus; Virology; CD8; NS5A; Immune system; Virus; Cytotoxic T cell; In vitro; Viral replication; Molecular biology; T cell; Hepacivirus; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002126496,0.000237046,0.0001865563,0.000165785,0.0001230852,0.0003509071,0.0001110876,0.0002238332,0.002703563],"category_scores_gemma":[0.0003351347,0.0001188822,0.0001852113,0.000143024,0.0001539221,0.0001543078,0.0001806691,0.0003742717,0.0008829467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001197942,"about_ca_system_score_gemma":0.00008481638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001476907,"about_ca_topic_score_gemma":0.0001450432,"domain_scores_codex":[0.9997806,0.00005890986,0.00002901535,0.00004914673,0.00004352876,0.00003891365],"domain_scores_gemma":[0.9997638,0.00009027591,0.00002299607,0.00005437445,0.00003241318,0.0000361681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003681461,0.00007768749,0.003787394,0.00006041475,0.000009683706,0.0001885934,0.00007430348,0.0001158693,0.9923126,0.00009368443,0.00009096162,0.002820651],"study_design_scores_gemma":[0.00008727516,0.003145748,0.03194223,0.00002135077,0.00006227842,0.004883355,0.0002561253,0.00311264,0.9512234,0.0001757623,0.005077926,0.00001199073],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996135,0.0004406102,0.001906471,0.00002246239,0.00001345715,0.00002401136,0.0002251258,0.00004267013,0.001190188],"genre_scores_gemma":[0.9953596,0.000213038,0.002038763,0.00003549222,0.00001672476,0.00004893603,0.0009879112,0.00001758734,0.001281955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002703563,"threshold_uncertainty_score":0.009044349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01672011070971157,"score_gpt":0.2814034879378379,"score_spread":0.2646833772281263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}