{"id":"W2770109786","doi":"10.1194/jlr.m078360","title":"PCSK9 deficiency reduces atherosclerosis, apolipoprotein B secretion, and endothelial dysfunction","year":2017,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; McGill University; Johns Hopkins University","keywords":"Apolipoprotein B; PCSK9; Secretion; Endothelial dysfunction; Apolipoprotein C2; Medicine; Internal medicine; Endocrinology; Lipoprotein; LDL receptor; Cholesterol; Very low-density lipoprotein","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001254347,0.0004135455,0.0003833433,0.0005558515,0.0001521871,0.0002607337,0.0002162237,0.000362344,0.001132148],"category_scores_gemma":[0.0001515953,0.0001640223,0.0002770677,0.0002303424,0.0001878488,0.0001561395,0.0001730179,0.0007897531,0.0002673495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002182185,"about_ca_system_score_gemma":0.0002019863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008257531,"about_ca_topic_score_gemma":0.0009311754,"domain_scores_codex":[0.9998389,0.00002048567,0.00002258941,0.00003425695,0.00004902956,0.00003460224],"domain_scores_gemma":[0.999755,0.00001481469,0.00008071806,0.00002587168,0.00002619327,0.00009739782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001548766,0.0002197074,0.0006642006,0.00006210326,0.00003533145,0.00007085931,0.000007327443,0.00007295067,0.9923327,0.0000482295,0.0001119608,0.004825869],"study_design_scores_gemma":[0.0002328784,0.00176851,0.03161885,0.00001676006,0.0001289517,0.0005399566,0.00003112715,0.0009165733,0.9618409,0.0001250209,0.002768489,0.00001190146],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995294,0.00143836,0.001290484,0.0001128453,0.00003618168,0.00001943773,0.0006821747,0.0002336556,0.00089288],"genre_scores_gemma":[0.9925013,0.001381211,0.001785994,0.00008797518,0.00002343171,0.00003721024,0.001033012,0.00005697916,0.003092941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001132148,"threshold_uncertainty_score":0.003787458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08187787674707826,"score_gpt":0.3748063028230781,"score_spread":0.2929284260759998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}