{"id":"W2770109786","doi":"10.1194/jlr.m078360","title":"PCSK9 deficiency reduces atherosclerosis, apolipoprotein B secretion, and endothelial dysfunction","year":2017,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; McGill University; Johns Hopkins University","keywords":"Apolipoprotein B; PCSK9; Secretion; Endothelial dysfunction; Apolipoprotein C2; Medicine; Internal medicine; Endocrinology; Lipoprotein; LDL receptor; Cholesterol; Very low-density lipoprotein","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006308688,0.0001132613,0.0003819801,0.0002822268,0.0008655395,0.0002034524,0.0002501232,0.0001273621,0.00009243556],"category_scores_gemma":[0.001311913,0.00007982639,0.0002113651,0.0001198651,0.0003459577,0.0002802285,0.0001114448,0.0008269493,0.00001928324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001322587,"about_ca_system_score_gemma":0.0004926528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000314374,"about_ca_topic_score_gemma":0.00001078336,"domain_scores_codex":[0.997114,0.0002655945,0.0004236532,0.0002045587,0.001589165,0.0004030355],"domain_scores_gemma":[0.9978161,0.00005374736,0.0002995769,0.0005757338,0.0009054401,0.0003494092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00200362,0.0007150386,0.03762687,0.0008241918,0.0004121951,0.0001386795,0.001379627,0.000005510246,0.5487645,0.001257859,0.005798358,0.4010735],"study_design_scores_gemma":[0.01208854,0.007351908,0.6932291,0.002024709,0.0002254552,0.003395486,0.001958406,0.0001302856,0.1413274,0.001544544,0.1362858,0.0004383541],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989751,0.001682846,0.0002183077,0.004432919,0.0005181287,0.0004152158,0.000003868667,0.000009019544,0.00296873],"genre_scores_gemma":[0.9920065,0.002527296,0.0005500954,0.00004689236,0.004010738,0.00001099291,8.642692e-7,0.00002227706,0.0008243274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6556023,"threshold_uncertainty_score":0.6657118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08187787674707826,"score_gpt":0.3748063028230781,"score_spread":0.2929284260759998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}