{"id":"W2770152266","doi":"10.1016/j.ibmb.2017.11.011","title":"Structural characterization of a lepidopteran type-II farnesyl diphosphate synthase from the spruce budworm, Choristoneura fumiferana: Implications for inhibitor design","year":2017,"lang":"en","type":"article","venue":"Insect Biochemistry and Molecular Biology","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Natural Resources Canada; Canadian Forest Service; Université Laval","funders":"National Research Council Canada; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Saskatchewan","keywords":"Spruce budworm; Juvenile hormone; Choristoneura fumiferana; Stereochemistry; Farnesyl diphosphate synthase; Biology; Mevalonate pathway; Biosynthesis; Active site; Biochemistry; Enzyme; Chemistry; Tortricidae; Lepidoptera genitalia; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010549,0.0005710797,0.0003457173,0.0001339071,0.000163559,0.0003835699,0.0003299089,0.0003163615,0.0005958448],"category_scores_gemma":[0.0001786606,0.0001766818,0.0003032118,0.0002509058,0.0001732564,0.0001997084,0.0001224026,0.0004870263,0.0001500453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005489541,"about_ca_system_score_gemma":0.0004639618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006039498,"about_ca_topic_score_gemma":0.005784251,"domain_scores_codex":[0.9999474,0.000005993198,0.000002986478,0.00001313014,0.00002145735,0.000009017738],"domain_scores_gemma":[0.9999114,0.00001616577,0.00002383938,0.000005255368,0.00001888064,0.0000244486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003114511,0.0000519923,0.003092442,0.0003915726,0.00005672293,0.0008519657,0.0001499857,0.003659775,0.9850838,0.0002153595,0.0003419707,0.00579309],"study_design_scores_gemma":[0.0001569583,0.0008665284,0.08487167,0.00006213896,0.0002257933,0.003026367,0.0007476214,0.02486152,0.8650671,0.0003737544,0.01966153,0.00007901382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931744,0.002570015,0.001845705,0.0001285,0.00001271338,0.00001810216,0.001110259,0.00005923109,0.001081067],"genre_scores_gemma":[0.9877481,0.002024368,0.003335,0.00004794496,0.00001130354,0.00001434352,0.00560287,0.00001841932,0.00119761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006039498,"threshold_uncertainty_score":0.01200867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02194240388908588,"score_gpt":0.2686035921956679,"score_spread":0.246661188306582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}