{"id":"W2770220785","doi":"10.1038/s41598-017-17079-6","title":"Cell-Free DNA Kinetics in a Pre-Clinical Model of Head and Neck Cancer","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Princess Margaret Cancer Foundation","keywords":"Head and neck squamous-cell carcinoma; Lymph node; Medicine; Head and neck cancer; Cancer; Pathology; Cancer research; Tumour heterogeneity; Cell-free fetal DNA; Head and neck; Oncology; Internal medicine; Biology; Surgery","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007222635,0.0004013257,0.0004430759,0.0002968776,0.000112302,0.0003730913,0.0004492463,0.0004545563,0.0009523034],"category_scores_gemma":[0.0006901264,0.0002022627,0.0002678712,0.0002143346,0.0005068026,0.000283559,0.0001838075,0.0007975014,0.0005165713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008703836,"about_ca_system_score_gemma":0.0004852138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003521168,"about_ca_topic_score_gemma":0.003112597,"domain_scores_codex":[0.9993692,0.0001726202,0.00003452172,0.0001671937,0.0001988427,0.00005762981],"domain_scores_gemma":[0.9993013,0.000236339,0.0001805185,0.0001216166,0.00009462691,0.00006566639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002894499,0.0001499142,0.0005845481,0.00007802103,0.000009381458,0.00004150841,0.00005927986,0.0008816713,0.9960551,0.000113208,0.00007802081,0.001659804],"study_design_scores_gemma":[0.00002732397,0.003989703,0.003282906,0.000009630257,0.00003145647,0.0003361064,0.00004261499,0.00615309,0.9835106,0.00009164003,0.002509242,0.00001567633],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9742513,0.003264111,0.01959308,0.000170032,0.00008208666,0.0002443176,0.0007049753,0.0001833276,0.00150665],"genre_scores_gemma":[0.9861167,0.001545413,0.008551179,0.00007660264,0.00001691977,0.0001567857,0.0007787634,0.00002983244,0.002727726],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003521168,"threshold_uncertainty_score":0.00700134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02734807911088778,"score_gpt":0.3195410319855366,"score_spread":0.2921929528746488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}