{"id":"W2770273110","doi":"10.1182/blood-2017-07-746453","title":"Age-related clonal hematopoiesis","year":2017,"lang":"en","type":"review","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":283,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Haematopoiesis; Biology; Progenitor cell; Stem cell; Somatic cell; Immunology; Stem cell theory of aging; Cancer; Somatic evolution in cancer; Genetics; Stem cell factor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004558646,0.0004802772,0.002720271,0.0003177313,0.0001771257,0.00007717072,0.0006477625,0.0008098106,0.000711669],"category_scores_gemma":[0.000580529,0.000353453,0.0009568549,0.0002167438,0.0002509471,0.00005210507,0.0003164881,0.001399809,0.002763966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002054275,"about_ca_system_score_gemma":0.001768085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002916052,"about_ca_topic_score_gemma":0.000002364603,"domain_scores_codex":[0.9974947,0.0001260482,0.0006673801,0.0005762539,0.0005808529,0.000554744],"domain_scores_gemma":[0.997408,0.0001874554,0.0003730197,0.001601046,0.00009860317,0.0003318617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000009724675,0.0004419746,0.00001045793,0.03728646,0.002539655,0.007101566,0.00003355537,4.443273e-9,0.000001998171,0.0003873021,0.01604945,0.9361379],"study_design_scores_gemma":[0.001627453,0.00008630608,0.00001120906,0.01622563,0.00457148,0.003149273,0.000002721657,4.288461e-7,0.000005599321,0.00004815631,0.9739783,0.0002934051],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00001381854,0.9528419,9.417414e-7,0.0001212201,0.0001693429,0.001082755,0.00004660226,0.000125206,0.04559816],"genre_scores_gemma":[0.000004267559,0.9668075,0.0003978594,0.00003749548,0.0005698038,0.0001388698,0.0003973547,0.0001354492,0.03151139],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9579289,"threshold_uncertainty_score":0.9998918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.107687962257405,"score_gpt":0.4030714379170683,"score_spread":0.2953834756596633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}