{"id":"W2770280942","doi":"10.1186/s12906-017-1993-8","title":"Fungal 7-epi-10-deacetyltaxol produced by an endophytic Pestalotiopsis microspora induces apoptosis in human hepatocellular carcinoma cell line (HepG2)","year":2017,"lang":"en","type":"article","venue":"BMC Complementary and Alternative Medicine","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Science and Engineering Research Board; Department of Biotechnology, Ministry of Science and Technology, India; Department of Science and Technology, Ministry of Science and Technology, India; York University; New York University Abu Dhabi; Indian Institute of Science","keywords":"Apoptosis; DNA fragmentation; Biology; Cell cycle; Cytotoxicity; Cell culture; Molecular biology; A549 cell; p38 mitogen-activated protein kinases; Cell cycle checkpoint; Fragmentation (computing); Chemistry; Protein kinase A; In vitro; Biochemistry; Kinase; Programmed cell death","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007043915,0.0004787079,0.0008437531,0.0002317386,0.0005878212,0.00006787448,0.0004521797,0.00007645105,0.001422693],"category_scores_gemma":[0.0001451121,0.0003651335,0.00008494307,0.000134744,0.0005027346,0.0003464384,0.0002307499,0.0004091357,0.00001069774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001070674,"about_ca_system_score_gemma":0.00005107626,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007443148,"about_ca_topic_score_gemma":0.0003333973,"domain_scores_codex":[0.9972112,0.0001647227,0.0007055269,0.00097837,0.0004146748,0.0005254949],"domain_scores_gemma":[0.9981849,0.00007815078,0.0004558321,0.0008058197,0.0001623302,0.0003130076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003380853,0.00043591,0.1955779,0.0002999895,0.00005706946,0.00006108488,0.0004512059,2.784749e-7,0.7994559,0.00002080891,0.002375548,0.000926144],"study_design_scores_gemma":[0.006434472,0.002076428,0.06166752,0.0003797343,0.000227228,0.00003390024,0.0006278564,0.0002158647,0.9254235,0.00005621986,0.002425092,0.0004321926],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936455,0.001118568,0.00001219786,0.003155875,0.0002780513,0.00122134,0.0002154181,0.00003744761,0.0003155507],"genre_scores_gemma":[0.9961138,0.0001446675,0.0003906554,0.0004731383,0.001182888,0.00001288462,0.0006448003,0.00004362485,0.0009934921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1339104,"threshold_uncertainty_score":0.9998801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06415331335156542,"score_gpt":0.3112869176312167,"score_spread":0.2471336042796513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}