{"id":"W2770308076","doi":"10.1038/mi.2017.91","title":"Intestinal epithelial cell-specific RARα depletion results in aberrant epithelial cell homeostasis and underdeveloped immune system","year":2017,"lang":"en","type":"article","venue":"Mucosal Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":59,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"National Institute of Allergy and Infectious Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; Alberta Innovates; Vetenskapsrådet; National Institutes of Health; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Immune system; Biology; Cell biology; Interleukin 22; KLF4; Goblet cell; Retinoic acid; Intestinal mucosa; Zebrafish; Innate lymphoid cell; Immunology; Homeostasis; Epithelium; Internal medicine; Innate immune system; Cytokine; Cell culture; Embryonic stem cell; Medicine; Interleukin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007687425,0.0004652944,0.0007018636,0.0004313833,0.0009789175,0.0001400881,0.0006099883,0.0006599086,0.0003013973],"category_scores_gemma":[0.000216472,0.0004451622,0.0001499843,0.0001308221,0.0006307663,0.0003816615,0.0003988274,0.001069946,0.001777168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002830724,"about_ca_system_score_gemma":0.0001147523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001504549,"about_ca_topic_score_gemma":0.0001037454,"domain_scores_codex":[0.9967197,0.000584882,0.00107254,0.0007798254,0.00007187598,0.0007711822],"domain_scores_gemma":[0.9977895,0.0002664076,0.0007373746,0.0009943199,0.0001749937,0.00003740554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004627412,0.0003117193,0.0005609072,0.00006494056,0.0001025837,0.00005886282,0.000784609,0.000004484223,0.978822,0.000794798,0.001648623,0.01221908],"study_design_scores_gemma":[0.01713584,0.001101998,0.120202,0.0002656086,0.00007933997,0.0009304939,0.00284047,0.00006402771,0.7085034,0.00009044326,0.1478401,0.0009461915],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9584658,0.01541929,0.0008654183,0.00100676,0.01236671,0.0006358239,0.00006087973,0.000236008,0.0109433],"genre_scores_gemma":[0.9919386,0.001864829,0.0001947626,0.00005391124,0.00009550039,0.00005619549,0.000300633,0.00005256766,0.005443017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2703185,"threshold_uncertainty_score":0.9998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01855951536262452,"score_gpt":0.2314139620871069,"score_spread":0.2128544467244824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}