{"id":"W2770376967","doi":"10.1093/hmg/ddx390","title":"COPD GWAS variant at 19q13.2 in relation with DNA methylation and gene expression","year":2017,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec; University of British Columbia","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Ministerie van Onderwijs, Cultuur en Wetenschap; Fonds Wetenschappelijk Onderzoek; Erasmus Medisch Centrum; ZonMw; Fonds de Recherche du Québec - Santé; Université Laval; Vlaamse regering; Universiteit Gent; European Commission; Canadian Institutes of Health Research; Cancer Research Society","keywords":"DNA methylation; Genome-wide association study; Epigenetics; Biology; COPD; Quantitative trait locus; Genetics; Expression quantitative trait loci; Epigenome; Genetic association; Methylation; Gene; Gene expression; Single-nucleotide polymorphism; Genotype; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002636065,0.0002114514,0.0001675156,0.00007520634,0.0003937749,0.00009553749,0.000192399,0.0002279779,0.00001173053],"category_scores_gemma":[0.00005794715,0.0002052835,0.00004200813,0.00003911726,0.0001232549,0.000008609217,0.0002380658,0.00009811654,0.000003952204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003013022,"about_ca_system_score_gemma":0.00003195198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002363346,"about_ca_topic_score_gemma":0.0001756386,"domain_scores_codex":[0.9986663,0.0001053823,0.0002693672,0.0005003949,0.000217521,0.0002410712],"domain_scores_gemma":[0.9987593,0.000008338011,0.0002434939,0.0008041264,0.00008446926,0.0001002741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005148018,0.00003184906,0.02970589,0.00001168247,0.00001693501,0.00002269787,0.00007286461,0.0008736818,0.9682615,0.0001269083,0.00001183361,0.000812675],"study_design_scores_gemma":[0.0008527766,0.0002177874,0.2585363,0.00002322414,0.0000221765,0.000007006822,0.000007071874,0.0001654488,0.7384264,0.0006335503,0.0008858912,0.0002223168],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839085,0.003149457,0.0114737,0.0000578958,0.00005761347,0.0002971318,0.000006874182,0.000008950458,0.001039886],"genre_scores_gemma":[0.9926066,0.0004502032,0.006333731,0.00004119382,0.00008422979,0.00002234112,0.0001839142,0.00004481294,0.0002329482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.229835,"threshold_uncertainty_score":0.837122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01501546777206308,"score_gpt":0.2701686638948642,"score_spread":0.2551531961228011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}