{"id":"W2770394202","doi":"10.1038/nsmb.3471","title":"Insights into a PCSK9 structural groove: a harbinger of new drugs to reduce LDL-cholesterol","year":2017,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"PCSK9; LDL receptor; Endosome; Proprotein convertase; Cholesterol; Chemistry; Kexin; Monoclonal antibody; Biochemistry; Receptor; Pharmacology; Cell biology; Antibody; Biology; Lipoprotein; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002739339,0.0004640308,0.0005571698,0.0001733384,0.0003997891,0.001054097,0.0005590034,0.0008172585,0.004777575],"category_scores_gemma":[0.0003739831,0.0002786849,0.0003861442,0.0001120046,0.0008855403,0.001804982,0.0008061056,0.002369197,0.001323815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004472219,"about_ca_system_score_gemma":0.0007072142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006224651,"about_ca_topic_score_gemma":0.0008668599,"domain_scores_codex":[0.9998993,0.00001065089,0.000005714118,0.0000152786,0.00003798661,0.00003099331],"domain_scores_gemma":[0.9998891,0.00002313193,0.00001774772,0.00001263862,0.00001891179,0.00003833746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002075663,0.0002283474,0.002404564,0.0008277588,0.0001154225,0.002972604,0.0004620239,0.008023155,0.7486392,0.09029399,0.01357147,0.1303858],"study_design_scores_gemma":[0.0008127292,0.003010095,0.006271561,0.0004073966,0.0003572009,0.005124414,0.001986168,0.02811823,0.4798216,0.1671517,0.3067376,0.0002012481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7740923,0.06146814,0.05121272,0.06322497,0.003405694,0.0001158114,0.001070902,0.001416784,0.04399272],"genre_scores_gemma":[0.9500651,0.02711892,0.00912057,0.004428752,0.000582822,0.00002126395,0.0002857403,0.00007864785,0.008298145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004777575,"threshold_uncertainty_score":0.01598263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008060991369240844,"score_gpt":0.3352241035150996,"score_spread":0.3271631121458588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}