{"id":"W2770479784","doi":"10.1002/cbic.201700428","title":"New WS9326A Derivatives and One New Annimycin Derivative with Antimalarial Activity are Produced by <i>Streptomyces asterosporus</i> DSM 41452 and Its Mutant","year":2017,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institutes of Health; National Center for Advancing Translational Sciences; Deutsche Forschungsgemeinschaft","keywords":"Gene cluster; Mutant; Polyketide; Gene; Biology; Polyketide synthase; Plasmodium falciparum; Streptomyces; Nonribosomal peptide; Biosynthesis; Stereochemistry; Genetics; Biochemistry; Chemistry; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007299007,0.0005089297,0.0002225091,0.0001571294,0.0001051253,0.0002342673,0.0001288587,0.0002212119,0.0008381627],"category_scores_gemma":[0.00008328499,0.0001006514,0.0002587953,0.000214012,0.0001055264,0.0001396473,0.0001707366,0.0003453135,0.0004018831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001542211,"about_ca_system_score_gemma":0.0001391791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003948618,"about_ca_topic_score_gemma":0.0005498404,"domain_scores_codex":[0.9999034,0.00001342204,0.00001274227,0.00002115378,0.00003282651,0.00001646708],"domain_scores_gemma":[0.9998825,0.00001333111,0.00004533311,0.00001670716,0.000008798221,0.00003333915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003405217,0.00001073751,0.0001367487,0.000009433868,0.000002555306,0.00009399333,0.000004867926,0.00004505005,0.9990314,0.00001870951,0.0000105823,0.0006019046],"study_design_scores_gemma":[0.000008083394,0.0002021703,0.005852195,0.000002839604,0.00001073353,0.0004558724,0.00003025714,0.0003359206,0.9909307,0.00002247834,0.002143841,0.000004913147],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996052,0.0004455845,0.00145479,0.00004703378,0.00001514591,0.00002384731,0.000515255,0.00006565099,0.001380724],"genre_scores_gemma":[0.9927016,0.0002562672,0.003286979,0.00002769132,0.000004705291,0.00001517718,0.001609905,0.00002830392,0.002069299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008381627,"threshold_uncertainty_score":0.002803922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0199155084250571,"score_gpt":0.2456366484936203,"score_spread":0.2257211400685632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}