{"id":"W2770603098","doi":"10.1101/220806","title":"Newly identified relatives of botulinum neurotoxins shed light on their molecular evolution","year":2017,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Botulinum Toxin and Related Neurological Disorders","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Intellectual and Developmental Disabilities Research Center; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Harvard Digestive Diseases Center, Harvard University; Burroughs Wellcome Fund; U.S. Department of Homeland Security","keywords":"Biology; Phylogenetic tree; Botulism; Clostridium botulinum; Phylogenetics; Genetics; Gene; Cytolethal distending toxin; Toxin; Genome; Molecular evolution; Homology (biology); Human pathogen; Evolutionary biology; Virulence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003068246,0.000415788,0.000546056,0.001443562,0.0005346793,0.0008707743,0.0003408395,0.0006697882,0.002198909],"category_scores_gemma":[0.0005255673,0.0002456106,0.0004747619,0.001588546,0.0002643432,0.0007376981,0.0006100619,0.0007368349,0.0009578099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004899739,"about_ca_system_score_gemma":0.0003561458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009647369,"about_ca_topic_score_gemma":0.001490956,"domain_scores_codex":[0.9998314,0.00001762536,0.00001403827,0.0000617083,0.00004584831,0.00002929798],"domain_scores_gemma":[0.9996477,0.0000819947,0.0001219612,0.00003248254,0.00005536897,0.00006048996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005075,0.0001335594,0.09758753,0.001446616,0.0001543682,0.004540264,0.0004884664,0.002519021,0.8218711,0.003497945,0.001068063,0.06618547],"study_design_scores_gemma":[0.00009037789,0.0007854725,0.6261919,0.0006900234,0.0005474596,0.02339295,0.00177657,0.02164564,0.1734057,0.00860527,0.1426973,0.0001714305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9743566,0.01223633,0.006461937,0.0005493389,0.00006682197,0.00003407316,0.002685513,0.0001826277,0.00342683],"genre_scores_gemma":[0.9661534,0.00680086,0.01730466,0.0003093719,0.00009289014,0.00002585243,0.006516565,0.00006007168,0.002736321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002198909,"threshold_uncertainty_score":0.007356048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01633960589389034,"score_gpt":0.2389569156180752,"score_spread":0.2226173097241849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}