{"id":"W2770623899","doi":"10.1089/aid.2017.0161","title":"Purging Exhausted Virus-Specific CD8 T Cell Phenotypes by Somatic Cell Reprogramming","year":2017,"lang":"en","type":"article","venue":"AIDS Research and Human Retroviruses","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto","funders":"UCLA AIDS Institute; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Bill and Melinda Gates Foundation","keywords":"Reprogramming; Biology; KLF4; Cytotoxic T cell; Induced pluripotent stem cell; Somatic cell; clone (Java method); SOX2; T cell; Virology; Cell biology; Immune system; Cell; Immunology; Genetics; In vitro; Gene; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005689437,0.000196445,0.0001909458,0.0001102469,0.00110963,0.0005006376,0.0004876838,0.0001383622,0.00006379181],"category_scores_gemma":[0.00008494744,0.0001924438,0.00006544202,0.00006098296,0.0003195113,0.00001652939,0.0003789051,0.0002764276,0.00002595913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001810336,"about_ca_system_score_gemma":0.00002898085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002228841,"about_ca_topic_score_gemma":0.00005094666,"domain_scores_codex":[0.9981832,0.00005928846,0.0002231502,0.0005570924,0.0003204494,0.0006568019],"domain_scores_gemma":[0.9985918,0.00003236002,0.00007738511,0.0009652183,0.000115312,0.0002178814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003387075,0.00009125186,0.0212594,0.0001011302,0.00002053232,0.000008739187,0.00008571961,0.00000473261,0.9681861,0.00007023027,0.007524206,0.002614075],"study_design_scores_gemma":[0.0006650759,0.0009037355,0.006645093,0.00003242917,0.000008939905,0.000003159712,0.000271061,0.000006771729,0.8757528,0.0001756196,0.1152531,0.0002821855],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889029,0.005657332,0.000782305,0.0000345372,0.00005921542,0.0002350524,0.00001484254,0.00002784705,0.004285924],"genre_scores_gemma":[0.9946685,0.00109748,0.0006326094,0.0000286459,0.0002725419,0.00003267384,0.00004595376,0.00004523997,0.003176336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1077289,"threshold_uncertainty_score":0.8534489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04030991721227249,"score_gpt":0.3725687123523322,"score_spread":0.3322587951400597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}