{"id":"W2770623899","doi":"10.1089/aid.2017.0161","title":"Purging Exhausted Virus-Specific CD8 T Cell Phenotypes by Somatic Cell Reprogramming","year":2017,"lang":"en","type":"article","venue":"AIDS Research and Human Retroviruses","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto","funders":"UCLA AIDS Institute; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Bill and Melinda Gates Foundation","keywords":"Reprogramming; Biology; KLF4; Cytotoxic T cell; Induced pluripotent stem cell; Somatic cell; clone (Java method); SOX2; T cell; Virology; Cell biology; Immune system; Cell; Immunology; Genetics; In vitro; Gene; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002928776,0.0003457588,0.0002997332,0.0002953534,0.0001588236,0.0004612894,0.0003124993,0.0003157167,0.00122341],"category_scores_gemma":[0.0001947864,0.0001734257,0.0002788975,0.0001825399,0.0002709373,0.0002422564,0.0004382966,0.000681039,0.0004556198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001305193,"about_ca_system_score_gemma":0.000179858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001322302,"about_ca_topic_score_gemma":0.0002685909,"domain_scores_codex":[0.9998063,0.00002204614,0.00003164342,0.00004714542,0.00005580501,0.00003710989],"domain_scores_gemma":[0.9998364,0.00004200851,0.00003390222,0.00004256267,0.00001982745,0.000025267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002824127,0.00002222851,0.0003060173,0.00002634842,0.00000367703,0.0000781139,0.00003435483,0.0001573266,0.9956167,0.0003687776,0.00003294272,0.003325351],"study_design_scores_gemma":[0.0000164689,0.0001570873,0.0008387013,0.000009479426,0.00002210141,0.0003474698,0.00001915138,0.001651981,0.9928658,0.000197502,0.003868578,0.000005638366],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.943305,0.0006961178,0.05127031,0.00008182774,0.00006424479,0.0002246259,0.0005707999,0.0003773388,0.003409722],"genre_scores_gemma":[0.9546639,0.0008882466,0.03850205,0.00009850225,0.00002706423,0.0002112567,0.0007832663,0.00009632052,0.004729418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00122341,"threshold_uncertainty_score":0.004092753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04030991721227249,"score_gpt":0.3725687123523322,"score_spread":0.3322587951400597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}