{"id":"W2770704163","doi":"10.1186/s12936-017-2109-0","title":"Synthetic oleanane triterpenoids enhance blood brain barrier integrity and improve survival in experimental cerebral malaria","year":2017,"lang":"en","type":"article","venue":"Malaria Journal","topic":"Malaria Research and Control","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto General Hospital; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"Artesunate; Cerebral Malaria; Plasmodium berghei; Medicine; Adjunctive treatment; Malaria; Artemisinin; Inflammation; Plasmodium falciparum; Combination therapy; Pharmacology; Parasitemia; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001256352,0.0003721503,0.0003332156,0.0002971556,0.00008567275,0.0001678527,0.0001939012,0.0001712012,0.001134307],"category_scores_gemma":[0.0001305348,0.00007432007,0.0001413023,0.0001478139,0.0002128902,0.0002006455,0.000117911,0.0005144059,0.0001475049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001229463,"about_ca_system_score_gemma":0.0002073969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00026781,"about_ca_topic_score_gemma":0.0005884529,"domain_scores_codex":[0.9999613,0.000007661146,0.000003410234,0.000005293271,0.000008477147,0.0000138955],"domain_scores_gemma":[0.9999012,0.00001425054,0.00003365976,0.000009629844,0.00001053676,0.00003087763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00310258,0.0007590284,0.0002234398,0.0001925165,0.00002304916,0.00008457647,0.00002731762,0.0002603969,0.9856914,0.0001261649,0.0001373627,0.009372259],"study_design_scores_gemma":[0.0005020034,0.01688555,0.005594749,0.00003259143,0.00008576058,0.0002527145,0.00004289107,0.0008453114,0.9731694,0.0001275012,0.002451483,0.00001016622],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961603,0.001860301,0.001000259,0.00009330174,0.00003175277,0.00004674129,0.0001525309,0.00005133928,0.0006034507],"genre_scores_gemma":[0.9943233,0.002378232,0.001944157,0.00004108355,0.00001778847,0.00006286781,0.0002536735,0.00001001103,0.0009689752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001134307,"threshold_uncertainty_score":0.003794611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01528568716903153,"score_gpt":0.3064293775510031,"score_spread":0.2911436903819715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}