{"id":"W2770707017","doi":"10.1007/978-1-4939-7522-8_6","title":"Three-Dimensional Co-Culture Bioassay for Screening of Retinal Gene Delivery Systems","year":2017,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"","keywords":"Bioassay; Neurite; Bioavailability; Gene delivery; Transfection; Retinal; Gene; Biology; Computational biology; Molecular biology; Chemistry; Pharmacology; Biochemistry; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006282763,0.001030399,0.0007107828,0.000899045,0.0005746711,0.0007210692,0.0008449886,0.0007519742,0.001177662],"category_scores_gemma":[0.0003860984,0.0003781834,0.0008939962,0.0007444808,0.0003255106,0.0003952985,0.0005985056,0.001084931,0.001163428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005230787,"about_ca_system_score_gemma":0.0004225389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001610188,"about_ca_topic_score_gemma":0.003124342,"domain_scores_codex":[0.9991257,0.0001893809,0.000102277,0.0001491347,0.0003522534,0.00008116049],"domain_scores_gemma":[0.9994339,0.0002227043,0.00009407884,0.00008357855,0.0001084364,0.00005725674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001488532,0.00003930558,0.00008331019,0.00002715233,0.000003752727,0.00002395255,0.00001742135,0.00006571131,0.9988496,0.0000485044,0.00002698225,0.0007992255],"study_design_scores_gemma":[0.000003287013,0.00009813784,0.0005961743,0.000005038695,0.00002343404,0.00007440714,0.00001795488,0.001097388,0.997183,0.0000280552,0.0008667558,0.000006395492],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.6509767,0.007205032,0.3297193,0.0003815191,0.0001881082,0.0007313904,0.001583615,0.0009334734,0.008280979],"genre_scores_gemma":[0.7234747,0.007183649,0.2415456,0.0002585308,0.00006799104,0.001933883,0.004385886,0.0002546927,0.02089498],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.001610188,"threshold_uncertainty_score":0.003939688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02932703039899068,"score_gpt":0.379110013624282,"score_spread":0.3497829832252913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}