{"id":"W2770707017","doi":"10.1007/978-1-4939-7522-8_6","title":"Three-Dimensional Co-Culture Bioassay for Screening of Retinal Gene Delivery Systems","year":2017,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"","keywords":"Bioassay; Neurite; Bioavailability; Gene delivery; Transfection; Retinal; Gene; Biology; Computational biology; Molecular biology; Chemistry; Pharmacology; Biochemistry; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001239751,0.0002067126,0.0003340729,0.00008166176,0.0001566908,0.00002408374,0.0004494973,0.000366113,0.000005517315],"category_scores_gemma":[0.0006071613,0.0001844929,0.0001588921,0.00004433338,0.0002897943,0.000003905063,0.0001920116,0.0001082368,0.000001037448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009734988,"about_ca_system_score_gemma":0.00007012342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009534177,"about_ca_topic_score_gemma":0.00002905438,"domain_scores_codex":[0.9984888,0.0002653421,0.0003656978,0.000470286,0.00008706802,0.0003227847],"domain_scores_gemma":[0.9989344,0.00004777433,0.0002911795,0.0005134322,0.0001559211,0.00005731245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002648183,0.00002956637,0.02118739,0.00003399041,0.00007667894,0.00000549788,0.00001087262,0.00008566156,0.9719322,0.0007741531,0.0002983484,0.00530077],"study_design_scores_gemma":[0.001648805,0.0005809372,0.007404167,0.00005619553,0.00003544932,0.00002788437,0.00003921037,0.0009061359,0.9702569,0.001807363,0.01680908,0.0004279068],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.1869407,0.002458447,0.8093082,0.00008698503,0.0002514491,0.0003622773,0.00003771589,0.000006425523,0.0005478144],"genre_scores_gemma":[0.137121,0.00008440562,0.8620438,0.0001206971,0.00008654716,0.00007774749,0.0003051751,0.00002743311,0.0001331908],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.05273559,"threshold_uncertainty_score":0.7523403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02932703039899068,"score_gpt":0.379110013624282,"score_spread":0.3497829832252913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}