{"id":"W2770713008","doi":"10.1186/s12860-017-0148-6","title":"Reduction of pluripotent gene expression in murine embryonic stem cells exposed to mechanical loading or Cyclo RGD peptide","year":2017,"lang":"en","type":"article","venue":"BMC Cell Biology","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bone and Joint Health Institute; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Calgary; Alberta Innovates; Alberta Innovates - Technology Futures","keywords":"Cell biology; Biology; Induced pluripotent stem cell; Embryonic stem cell; Leukemia inhibitory factor; Integrin; Mesoderm; Ectoderm; Transcription factor; Cellular differentiation; Homeobox protein NANOG; Molecular biology; Cell; Embryo; Embryogenesis; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005315371,0.0002488753,0.0003847828,0.0001567534,0.0001447714,0.0000256197,0.0007428622,0.0003753053,0.00005354554],"category_scores_gemma":[0.00008502881,0.0002089458,0.0001337563,0.0000829031,0.0001209212,0.000008576724,0.000781745,0.0001842921,0.00005131619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006154598,"about_ca_system_score_gemma":0.0001547759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005881767,"about_ca_topic_score_gemma":0.0001206047,"domain_scores_codex":[0.9977694,0.0002553038,0.0004637779,0.0007811183,0.0001657411,0.0005646255],"domain_scores_gemma":[0.9983088,0.00003385208,0.0002732442,0.001097069,0.0000963443,0.000190626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008726111,0.000153637,0.000927484,0.00008311959,0.00001353535,0.00001165542,0.00003242448,0.0002502091,0.9964886,0.000007326334,0.0003899383,0.0007695096],"study_design_scores_gemma":[0.001285258,0.000760411,0.0006323156,0.00004989611,0.000008720559,0.00001654604,0.00009595214,0.0001202014,0.9934402,0.00001886733,0.003332638,0.0002389906],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963756,0.0002866264,0.001638678,0.00008431357,0.0004366345,0.0005796325,0.00002663144,0.00001256852,0.0005593622],"genre_scores_gemma":[0.9919291,0.0003478043,0.003731627,0.000024783,0.0002261671,0.00005996807,0.00004684243,0.0000345452,0.003599234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004446524,"threshold_uncertainty_score":0.8520561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03463165362423925,"score_gpt":0.2912161809774261,"score_spread":0.2565845273531869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}