{"id":"W2770713008","doi":"10.1186/s12860-017-0148-6","title":"Reduction of pluripotent gene expression in murine embryonic stem cells exposed to mechanical loading or Cyclo RGD peptide","year":2017,"lang":"en","type":"article","venue":"BMC Cell Biology","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bone and Joint Health Institute; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Calgary; Alberta Innovates; Alberta Innovates - Technology Futures","keywords":"Cell biology; Biology; Induced pluripotent stem cell; Embryonic stem cell; Leukemia inhibitory factor; Integrin; Mesoderm; Ectoderm; Transcription factor; Cellular differentiation; Homeobox protein NANOG; Molecular biology; Cell; Embryo; Embryogenesis; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009346651,0.0002518825,0.0001132346,0.0001277086,0.00006341512,0.0001295268,0.00009244273,0.0001856276,0.001076266],"category_scores_gemma":[0.00006690868,0.00007916212,0.0001344112,0.0000699447,0.0001611115,0.0000775651,0.0001108895,0.000276005,0.0001450685],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001123524,"about_ca_system_score_gemma":0.00008347693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002001352,"about_ca_topic_score_gemma":0.0002929483,"domain_scores_codex":[0.9999049,0.00001329675,0.00001120887,0.00001688982,0.00003743276,0.00001627018],"domain_scores_gemma":[0.9999282,0.0000153518,0.00002269177,0.000006653804,0.000008383072,0.00001880519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001463867,0.000003472619,0.00005374259,0.00001473508,0.000001238598,0.00001136743,0.000003456185,0.00001515193,0.9995709,0.00001702864,0.000005293036,0.0002890415],"study_design_scores_gemma":[0.000004127548,0.0001657716,0.002572029,0.000003740366,0.000007467891,0.00005838554,0.000008065387,0.0002197184,0.996269,0.000009735536,0.000680535,0.000001265287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954971,0.001116467,0.00194873,0.00004315435,0.00002238963,0.00002378222,0.000249547,0.00003529435,0.001063526],"genre_scores_gemma":[0.9946501,0.0007645437,0.001689428,0.00006289615,0.000008504004,0.00004987657,0.0004431668,0.00001334369,0.002318029],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001076266,"threshold_uncertainty_score":0.003600419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03463165362423925,"score_gpt":0.2912161809774261,"score_spread":0.2565845273531869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}