{"id":"W2770731797","doi":"10.1016/j.tim.2017.10.007","title":"Impact of HIV-1 Envelope Conformation on ADCC Responses","year":2017,"lang":"en","type":"review","venue":"Trends in Microbiology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":92,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research; amfAR, The Foundation for AIDS Research","keywords":"Biology; Envelope (radar); Human immunodeficiency virus (HIV); Antibody-dependent cell-mediated cytotoxicity; Virology; Computational biology; Genetics; Telecommunications; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.000441707,0.0005324832,0.002211171,0.001461928,0.0001219384,0.000009574574,0.000689029,0.001039554,0.002529659],"category_scores_gemma":[0.0001745882,0.0003549529,0.0007494937,0.0001998138,0.0005392929,0.00005679064,0.0001651713,0.0007596533,0.005743224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003289362,"about_ca_system_score_gemma":0.0004848059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001195792,"about_ca_topic_score_gemma":0.00005060658,"domain_scores_codex":[0.9969756,0.001005649,0.0008659546,0.0004645247,0.0000209161,0.0006673757],"domain_scores_gemma":[0.9978292,0.0004992539,0.0007058377,0.0008778818,0.00005376735,0.00003408131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003803993,0.000259985,0.0002256034,0.0004755556,0.000894559,0.00003208762,0.00009311069,3.714549e-7,0.0004282695,0.00004371357,0.01486465,0.9823017],"study_design_scores_gemma":[0.001371637,0.001048556,0.001220229,0.00175909,0.0001387351,0.0003094349,0.000004834034,2.220242e-8,0.00009078118,0.000003633142,0.993773,0.0002800305],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009743379,0.9884087,8.98046e-7,0.00001987247,0.0002945253,0.0003755962,0.005019874,0.00002656519,0.00487959],"genre_scores_gemma":[0.003107939,0.9699785,0.00001877707,0.000006057585,0.00002194391,0.00008803426,0.01493595,0.00003137308,0.01181144],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9820217,"threshold_uncertainty_score":0.9998903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1163515379289668,"score_gpt":0.4332563002567856,"score_spread":0.3169047623278187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}