{"id":"W2770804597","doi":"10.1074/jbc.m117.813428","title":"A neutralizing antibody that blocks delivery of the enzymatic cargo of Clostridium difficile toxin TcdB into host cells","year":2017,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; U.S. Department of Veterans Affairs","keywords":"Clostridium difficile; Clostridium difficile toxin A; Toxin; Clostridium difficile toxin B; Microbiology; Neutralizing antibody; Antibody; Virology; Pore-forming toxin; Host (biology); Enzyme; Microbial toxins; Biology; Virus; Immunology; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000536352,0.0002469677,0.0008442479,0.00005413839,0.0001892414,0.00003752013,0.0009014051,0.0003354969,0.0002411255],"category_scores_gemma":[0.0007510012,0.0001415641,0.0006345439,0.000134876,0.0006382027,0.0000613831,0.0003710346,0.0007917267,0.000002659525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001128181,"about_ca_system_score_gemma":0.0003148775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000785147,"about_ca_topic_score_gemma":0.000001754476,"domain_scores_codex":[0.9977967,0.00006714823,0.0008698359,0.0002322268,0.0006690131,0.0003650527],"domain_scores_gemma":[0.9970351,0.0002585631,0.001258042,0.0007740636,0.0004469167,0.0002273463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004269821,0.0004408898,0.01253398,0.0003938716,0.0001322087,0.00007956613,0.00007799611,0.00000582776,0.9849927,0.000002810973,0.0005326407,0.0003805222],"study_design_scores_gemma":[0.001288817,0.0004292767,0.009618479,0.000649714,0.0001342948,0.0001860225,0.0003893079,0.0000333507,0.9866777,0.00002353858,0.0004342773,0.0001351975],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965192,0.001047705,0.000006373105,0.0007451926,0.0001798482,0.0001830295,0.00003540687,0.000007771256,0.001275472],"genre_scores_gemma":[0.9983295,0.000865902,0.0001293019,0.00003967194,0.0003498919,0.000001922573,0.000005208704,0.00001517511,0.0002633949],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0029155,"threshold_uncertainty_score":0.5772815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0429942720247378,"score_gpt":0.3154007838877659,"score_spread":0.2724065118630281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}